damt-1 Antibody
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In Stock 
Product Specs
Buffer
**Preservative:** 0.03% Proclin 300
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
damt-1 antibody; C18A3.1DNA N6-methyl methyltransferase antibody; EC 2.1.1.72 antibody; DNA N6 adenine methyltransferase 1 antibody
Target Names
damt-1
Uniprot No.
Target Background
Function
This antibody targets DNA methyltransferase 1 (DAMT-1), an enzyme involved in the methylation of adenine at the 6th position (N(6)-methyladenosine, m6A). m6A DNA plays a crucial role in epigenetic transgenerational inheritance, influencing the transmission of heritable traits without alterations in the underlying DNA sequence.
Gene References Into Functions
- A study identified a DNA demethylase, NMAD-1, and a potential DNA methyltransferase, DAMT-1, which regulate 6mA levels and exhibit crosstalk between methylation modifications of histone H3K4 and adenines. The study suggests that C18A3.1 is the primary 6mA DNA methylase candidate in C. elegans. PMID: 25936839
Database Links
Protein Families
MT-A70-like family
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