dapk-1 Antibody
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
dapk-1 antibody; mor-3 antibody; tag-119 antibody; K12C11.4Death-associated protein kinase dapk-1 antibody; EC 2.7.11.1 antibody
Target Names
dapk-1
Uniprot No.
Target Background
Function
DAPK-1 is a negative regulator of epidermal barrier repair and innate immune responses to wounding. Its role in epidermal tissue integrity and wound healing is established through the inhibition of epidermal microtubule stability, potentially via the negative regulation of the microtubule minus-end binding protein ptrn-1. Within the epidermis, DAPK-1 prevents the expression of specific unc-44 isoforms, likely by promoting nuclear localization of pinn-1. This, in turn, may influence the sydn-1-ssup-72-mediated regulation of alternative polyadenylation of unc-44 mRNA. DAPK-1 appears to function downstream of or in parallel to muscarinic signaling in the regulation of autophagy.
Gene References Into Functions
- Loss of sydn-1 blocks ectopic expression of neuronal ankyrin and suppresses epidermal morphology defects associated with dapk-1. The effects of sydn-1 are mediated autonomously by ssup-72 within the epidermis. PMID: 28087624
- Research highlights the significant role of DAPK and Pin1/PINN-1 as conserved mediators of cell death processes in various scenarios of neurodegeneration. PMID: 25899010
- The death-associated protein kinase DAPK-1 functions as a negative regulator of wound closure. PMID: 22100061
- Death-associated protein kinase (DAPK) plays a crucial role in signal transduction, specifically in fine-tuning autophagy during homeostasis. Review. PMID: 19878311
- Overexpression of DAPK-1 suppresses innate immune responses to needle wounding. PMID: 19164535
Database Links
Protein Families
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, DAP kinase subfamily
Subcellular Location
Cytoplasm, cytosol. Cytoplasm, cytoskeleton.
Tissue Specificity
Expressed in epidermis, muscles and neurons.
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