DBF4B Antibody
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
We typically dispatch products within 1-3 business days of receiving your order. Delivery times may vary depending on your location and shipping method. Please consult your local distributor for specific delivery timelines.
Synonyms
Activator of S phase kinase like protein 1 antibody; Activator of S phase kinase-like protein 1 antibody; ASK like protein 1 antibody; ASK-like protein 1 antibody; ASKL1 antibody; chifb antibody; Chiffon homolog B antibody; DBF 4B antibody; DBF4 homolog B (S. cerevisiae) antibody; DBF4 homolog B antibody; Dbf4 related factor 1 antibody; Dbf4-related factor 1 antibody; dbf4b antibody; DBF4B_HUMAN antibody; DRF1 antibody; FLJ13087 antibody; MGC15009 antibody; Protein DBF4 homolog B antibody; ZDBF1B antibody; Zinc finger DBF type containing 1B antibody
Target Names
DBF4B
Uniprot No.
Target Background
Function
DBF4B is a regulatory subunit for CDC7. It activates CDC7's kinase activity, playing a crucial role in DNA replication and cell proliferation. DBF4B is essential for the progression of the S and M phases of the cell cycle. The CDC7-DBF4B complex specifically phosphorylates the MCM2 subunit at serine 40, which is involved in regulating the initiation of DNA replication during the cell cycle.
Gene References Into Functions
- Knockdown of the exon6-containing isoform (DBF4B-FL) significantly inhibits the tumorigenic potential of colon cancer. Overexpression of DBF4B-FL protects against DNA damage induced by SRSF1 knockdown. PMID: 29262322
- Research has identified a novel human protein, Drf1, related to both human and yeast Dbf4. Drf1 is a nuclear cell cycle-regulated protein that binds to Cdc7 and activates its kinase activity. PMID: 12065429
- ASKL1, in a complex with Cdc7, may contribute to the normal progression of both S and M phases. PMID: 15668232
- These findings suggest that Ddk acts as an upstream regulator in monitoring S-phase checkpoint signaling. PMID: 19111665
Database Links
Subcellular Location
Nucleus. Note=Predominantly found in soluble fraction but not in the chromatin-bound fraction.
Tissue Specificity
Widely expressed. Highly expressed in testis.
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