SAMDC3 Antibody

Definition and Target Specificity

SAMDC3 antibody specifically binds to the SAMDC3 enzyme (UniProt ID: Q8N6K7), which catalyzes the decarboxylation of S-adenosylmethionine to form decarboxylated S-adenosylmethionine—a critical step in polyamine synthesis . Key characteristics include:

Applications in Research

SAMDC3 antibodies are pivotal in studying polyamine metabolism and host-pathogen interactions:

Key Applications

• Western Blot: Detects SAMDC3 in lysates from HSCT6, HSC-T6, and ROS1728 cell lines at dilutions of 1:1,000–1:4,000 .

• Antiviral Mechanisms: SAMDC3 enhances resistance to Barley stripe mosaic virus (BSMV) by ubiquitinating and degrading the viral γb protein via the 26S proteasome .

• Plant Immunity Studies: SAMDC3-mediated polyamine pathways regulate reactive oxygen species (ROS) and salicylic acid (SA) signaling in Nicotiana benthamiana .

Biochemical Characteristics

Commercial SAMDC3 antibodies exhibit distinct biochemical profiles:

Key Research Findings

Recent studies highlight SAMDC3's role in antiviral defense:

Table 1: SAMDC3 in Viral Resistance

• Ubiquitination Cascade: SAMDC3 recruits E3 ligases to tag viral proteins for degradation, limiting viral replication .

• Polyamine Crosstalk: SAMDC3 activity correlates with increased spermidine levels, which stabilize defense-related mRNAs .