dcr-1 Antibody
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
dcr-1 antibody; K12H4.8Endoribonuclease dcr-1 antibody; EC 3.1.26.-) [Cleaved into: Death-promoting deoxyribonuclease antibody; tDCR-1 antibody; EC 3.1.21.-)] antibody
Target Names
dcr-1
Uniprot No.
Target Background
Function
DCR-1 is a component of the ERI/DICER complex, which plays a crucial role in processing amplified double-stranded RNA (dsRNA) intermediates during small-RNA-mediated gene silencing or RNA interference (RNAi). It is involved in cleaving dsRNA in the RNAi pathway, producing 21 to 23 bp dsRNAs (siRNAs) that target the selective destruction of homologous RNAs. DCR-1 is also implicated in the processing of the precursor of the small temporal RNA let-7, which is involved in developmental timing. Furthermore, it is essential for avoidance behavior induced by small RNAs derived from pathogenic bacteria such as P. aeruginosa, contributing to innate immunity through its role in small RNA processing. Notably, DCR-1 also exhibits deoxyribonuclease (DNase) activity, initiating DNA fragmentation during apoptosis, upstream of nucleases cps-6, crn-2, and nuc-1.
Gene References Into Functions
- A comprehensive transcriptome-wide map of Dicer targets identified thousands of Dicer-binding sites in human cells and C. elegans. This study identified known and hundreds of additional miRNAs, highlighting structural RNAs, promoter RNAs, and mitochondrial transcripts as Dicer targets. Notably, most Dicer-binding sites reside on mRNAs/lncRNAs and are not significantly processed into small RNAs. PMID: 25416952
- Cleavage of DCR-1 by caspase 3 may induce a conformational change, enabling truncated DCR-1 to bind and process DNA. This cleavage might remove steric hindrance that previously blocked DNA access to truncated DCR-1. PMID: 24323044
- [Review] Dicer-1 lacks a functional helicase domain and is primarily responsible for processing pre-microRNAs into mature miRNAs. PMID: 24556400
- These findings uncover a previously unknown role for DCR-1/Dicer in C. elegans antibacterial immunity, predominantly associated with miRNA processing. PMID: 23918784
- The helicase domain of Dicer discriminates dsRNA termini to promote an altered reaction mode. PMID: 21362554
- The helicase domain of Dicer is not essential for microRNA (miRNA) processing or RNA interference following exposure to exogenous double-stranded RNA. PMID: 20354150
- Research indicates that DCR-1 functions in fragmenting chromosomal DNA during apoptosis, alongside its role in processing small RNAs. Moreover, it undergoes a protease-mediated conversion from a ribonuclease to a deoxyribonuclease. PMID: 20223951
- These findings provide insights into the complex biochemical niche of Dicer, suggesting competition exists between DCR-1-mediated small-RNA pathways. PMID: 16439208
- Knock-out animals Dcr-/- exhibit increased expression of innate immunity genes. PMID: 17526642
Database Links
Protein Families
Helicase family, Dicer subfamily
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