DDR1 (Ab-796) Antibody

1. Research using knockout mice suggests that DDR1 plays a role in promoting mammary tumor growth. Extrinsic DDR1 appears to be necessary for the promotion of mammary tumors by interleukin-6. PMID: 29298894
2. A recent study has identified a novel regulatory pathway involving TM4SF1, DDR1, MMP2, and MMP9, which promotes the formation and function of invadopodia, supporting cell migration and invasion in pancreatic cancer. PMID: 28368050
3. The three well-conserved seed matched sites for miR-199a/b-5p in the discoidin domain receptor 1 (DDR1) 3'-UTR were targeted, and miRNA binding to at least two sites was required for DDR1 inhibition. PMID: 29429150
4. E2F1 knockdown decreased the expression of discoidin domain receptor 1 (DDR1) which plays a crucial role in many fundamental processes such as cell differentiation, adhesion, migration, and invasion. PMID: 29039472
5. Furthermore, inhibition of DDR1 with 7rh showed striking efficacy in combination with chemotherapy in orthotopic xenografts and autochthonous pancreatic tumors where it significantly reduced DDR1 activation and downstream signaling, reduced primary tumor burden, and improved chemoresponse. PMID: 28864681
6. These findings demonstrate a critical role of the miR-199a-3p/DDR1 pathway in ovarian cancer development. PMID: 28743276
7. Research indicates that in human breast cancer cells, DDR1 regulates IR expression and ligand-dependent biological actions. This novel functional crosstalk is likely clinically relevant. PMID: 28591735
8. These results support an activation mechanism of DDR1 whereby collagen induces lateral association of DDR1 dimers and phosphorylation between dimers. PMID: 28590245
9. Data suggest that the IGF-I/IGF-IR system triggers stimulatory actions through both GPER and DDR1 in aggressive tumors such as mesothelioma and lung tumors. PMID: 27384677
10. Analysis of CpG methylation levels at the DDR1 promoter in EOC cells revealed a negative correlation between the CpG methylation levels of the DDR1 promoter and the expression of DDR1 along the EMT spectrum. Therefore, EMT stratification could be a potential biomarker to predict patient response to DDR1-targeting drugs. PMID: 28887161
11. This study suggests that DDR1 and DDR2 knockdown alters brain immunity and significantly reduces the level of triggering receptor expressed on myeloid cells (TREM)-2 and microglia. PMID: 28863860
12. Isoform b of DDR1 is responsible for collagen I-induced up-regulation of N-cadherin, and tyrosine 513 of DDR1b is necessary for this process. PMID: 27605668
13. Reduced DDR1 expression may be implicated in impaired melanocyte adhesion involved in vitiligo pathogenesis. PMID: 26091274
14. Data demonstrate that TGF-beta1 favors linear invadosome formation through the expressions of both inducers, such as collagen and LOXL2, and components such as DDR1 and MT1-MMP of linear invadosomes in cancer cells. Furthermore, these data uncover a new TGF-beta1-dependent regulation of DDR1 expression. PMID: 27720259
15. DDR1 overexpression promoted GC cell proliferation (p < 0.05), migration (p < 0.01), and invasion (p < 0.01), and accelerated the growth (p < 0.05) as well as the microvessel formation (p < 0.01) of transplantation tumor in nude mice. PMID: 27179963
16. Our results suggest that DDR1 is both a prognostic marker for renal clear cell carcinoma and a potential functional target for therapy. PMID: 27020590
17. This study concludes that non-canonical DDR1 signaling enables breast cancer cells to exploit the ubiquitous interstitial matrix component collagen I to undergo metastatic reactivation in multiple target organs. PMID: 27368100
18. Upregulation of the DDR1 collagen receptor is associated with breast cancer. PMID: 26655502
19. Knockdown of DDR1 reversed the effects of Galpha13 knockdown on cell-cell adhesion and proteolytic invasion in a three-dimensional collagen environment. PMID: 26589794
20. Data suggest that SCl2 (Streptococcus pyogenes) binds to the DDR (DDR1, DDR2) ectodomain without stimulating receptor signaling. Protein engineering was used to construct SCl-like proteins that inhibit collagen-DDR interactions and macrophage migration. PMID: 26702058
21. DDR1 is a key modulator of RIT activity. PMID: 26719540
22. DDR1 expression is a prognostic indicator in pancreatic ductal carcinoma. PMID: 26297342
23. alpha5(IV), but not alpha1(IV), promotes lung cancer cell proliferation and tumor angiogenesis through non-integrin collagen receptor DDR1-mediated ERK activation. PMID: 25992553
24. Hypoxia can increase DDR1 expression in pituitary adenoma cells, leading to improved MMP-2 and MMP-9 secretion, and promoting pituitary adenoma cell proliferation and invasion. PMID: 26286316
25. Research suggests that DDR1 suppression may enhance adipose-derived stem cell chondrogenesis by enhancing the expression of chondrogenic genes and cartilaginous matrix deposition. PMID: 25673773
26. The MT1-MMP-discoidin domain receptor 1 axis regulates collagen-induced apoptosis in breast cancer cells. PMID: 25774665
27. Defective Ca(2+) binding in a conserved binding site causes incomplete N-glycan processing and endoplasmic reticulum trapping of DDR1 and DDR2 receptors. PMID: 25470979
28. A DDR1(Low)/DDR2(High) protein profile is associated with TNBC and may identify invasive carcinomas with worse prognosis. PMID: 25667101
29. Ten new mutations in TNK2 and DDR1 within serous and endometrioid ECs were identified, providing novel insights into the mutation spectrum of each gene in EC. PMID: 25427824
30. Silencing of DDR1 inhibited tumor cell growth and motility, and induced TGFBI expression, both in vitro and in vivo. PMID: 25369402
31. Research found an inverse correlation between ZEB1 and DDR1 expression in various cancer cell lines and in human breast carcinoma tissues. PMID: 25155634
32. DDR1 depletion blocked cell invasion in a collagen gel. PMID: 25422375
33. The expression of the DDR1 protein significantly correlated with poor disease-free survival in patients with serous ovarian cancer. PMID: 21541037
34. High DDR1 protein expression is associated with recurrence in ameloblastomas. PMID: 24723326
35. This review highlights the mechanisms by which DDRs (DDR1 and DDR2) regulate two important processes: inflammation and tissue fibrosis. PMID: 24361528
36. Aberrant methylation of DDR1 has been reported in men with nonobstructive azoospermia. PMID: 25064398
37. Crystal structures of DDR1 reveal a DFG-out conformation (DFG, Asp-Phe-Gly) of the kinase domain, stabilized by a salt bridge between the activation loop and alphaD helix. Differences to Abelson kinase are observed in the DDR1 P-loop's beta-hairpin. PMID: 24768818
38. These findings indicate that the extracellular juxtamembrane region of DDR1 is exceptionally flexible and does not constrain the basal or ligand-activated state of the receptor. PMID: 24671415
39. N-glycosylation at the highly conserved (211)NDS motif evolved to act as a negative repressor of DDR1 phosphorylation in the absence of ligand. PMID: 24509848
40. Regulation of DDRs by glucose. PMID: 24018687
41. Upregulation of DDR1 induced by collagen I may contribute to the development and progression of NSCLC. PMID: 23761027
42. The DDR1 extracellular domain plays a crucial role in receptor oligomerization, which mediates high-affinity interactions with its ligand. PMID: 23810922
43. Research shows that expression of the latent LMP1 in primary human germinal center B cells, the presumed progenitors of HRS cells, upregulates discoidin domain receptor 1 (DDR1), a receptor tyrosine kinase activated by collagen. PMID: 24136166
44. These data suggest that NEP can augment taxane-induced apoptosis through inhibition of Akt/Bad signaling. PMID: 22895534
45. Research demonstrates the expression of the novel collagen receptor discoidin domain receptor 1 (DDR1) by human MKs at both mRNA and protein levels and provides evidence of DDR1 involvement in the regulation of MK motility on type I collagen. PMID: 23530036
46. DDR1 expression was not predictive for patient survival in human breast cancer. PMID: 23307244
47. DD1 mRNA and protein levels were higher in patients with recurrent Hepatocellular carcinoma, suggesting this gene may be involved in tumor invasion and metastasis. PMID: 22752569
48. Research suggests a role for the collagenase of membrane-type MMPs in the regulation of DDR1 cleavage and activation at the cell-matrix interface. PMID: 23519472
49. Discoidin domain receptors promote alpha1beta1- and alpha2beta1-integrin mediated cell adhesion to collagen by enhancing integrin activation. PMID: 23284937
50. Discoidin domain receptors are unique receptor tyrosine kinases in collagen-mediated signaling [review]. PMID: 23335507

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HGNC: 2730

OMIM: 600408

KEGG: hsa:780

STRING: 9606.ENSP00000365759

UniGene: Hs.631988