Customize ddr-1 Antibody

Description

Overview of DDR1 Antibody

DDR1 antibodies are designed to inhibit or modulate DDR1, a transmembrane receptor that binds collagen and regulates extracellular matrix (ECM) remodeling. DDR1 is overexpressed in epithelial cancers (e.g., breast, lung, pancreatic) and fibrotic diseases, where it promotes tumor invasion, metastasis, and immune evasion .

Key Features of DDR1 Antibodies

Target: Extracellular domain (ECD) or kinase domain of DDR1 .
Applications: Research (e.g., immunohistochemistry, Western blot), therapeutic development .
Relevance: High DDR1 expression correlates with poor prognosis in cancers and resistance to immunotherapy .

Mechanism of Action

DDR1 antibodies disrupt collagen-DDR1 interactions or downstream signaling:

Functional Mechanisms

Mechanism	Effect	Example Antibody
Block collagen binding	Prevents DDR1 activation and ECM remodeling	PRTH-101
Inhibit kinase activity	Reduces phosphorylation and downstream signaling (e.g., EZH2, NF-κB)	BSB-173
Disrupt collagen alignment	Breaks physical tumor barriers, enhancing T-cell infiltration	PRTH-101
Prevent DDR1 shedding	Stabilizes DDR1 on cell surface, reducing soluble ECD-mediated effects	PRTH-101

Preclinical Insights

Immune Exclusion: DDR1 promotes collagen fiber alignment, forming a physical barrier that excludes CD8+ T cells from tumors. Antibodies like PRTH-101 disrupt this barrier, restoring antitumor immunity .
Metastasis: DDR1 activation in pancreatic cancer induces CXCL5 secretion, recruiting neutrophils and driving metastasis via NETosis .
Therapeutic Synergy: Combining DDR1 antibodies (e.g., PRTH-101) with PD-1 inhibitors enhances tumor regression in microsatellite-stable colorectal cancer models .

Clinical Development

Antibody	Stage	Indication	Key Findings
PRTH-101	Phase 1c	Advanced solid tumors	Safe and tolerable; disrupts collagen barriers, enhances T-cell infiltration .
BSB-173	Research use	FFPE tissue staining	Validated for cytoplasmic DDR1 detection in cancer tissues .
AF2396	Research use	Western blot/ELISA	Detects DDR1 at ~100–140 kDa; cross-reacts weakly with DDR2 .

Therapeutic Potential

Immune Modulation: DDR1 antibodies reverse immune exclusion, sensitizing tumors to checkpoint inhibitors .
Biomarker-Driven Use: High DDR1/collagen I expression predicts response in colorectal, breast, and lung cancers .
Safety: PRTH-101 shows no significant toxicity in Phase 1 trials, supporting further development .

Challenges and Future Directions

Target Specificity: DDR1 and DDR2 share structural homology, necessitating selective antibodies .
Resistance Mechanisms: Tumor heterogeneity and compensatory pathways (e.g., alternative collagen receptors) may limit efficacy.
Combination Strategies: Ongoing trials explore DDR1 antibodies with chemotherapy, radiation, or immunotherapy .

Product Specs

Buffer

**Preservative:** 0.03% Proclin 300
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Lead Time

Made-to-order (14-16 weeks)

Synonyms

ddr-1 antibody; C25F6.4Discoidin domain-containing receptor A antibody

Target Names

ddr-1

Uniprot No.

Q18163

Target Background

Function

DDR-1 is a receptor that, in conjunction with SVH-4, participates in axon guidance during nervous system development, establishing the tracts for the ventral and dorsal nerve cords. It may play a role in promoting axon regeneration following injury in D-type motor neurons.

Database Links

KEGG: cel:CELE_C25F6.4

STRING: 6239.C25F6.4

UniGene: Cel.11305

Protein Families

Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily

Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Perikaryon.

Tissue Specificity

Expressed in neurons in head and tail, some motoneurons in ventral nerve cord, in PVP interneurons, pharynx and stomato-intestinal muscle.

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ddr-1 Antibody