ddx11 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% ProClin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
14-16 week lead time (made-to-order)
Synonyms
ddx11 antibody; zgc:92172ATP-dependent DNA helicase DDX11 antibody; EC 3.6.4.12 antibody; DEAD/H-box protein 11 antibody
Target Names
ddx11
Uniprot No.
Target Background
Function
DDX11 is a DNA-dependent ATPase and ATP-dependent DNA helicase crucial for genomic stability. Its functions encompass DNA replication, repair, and heterochromatin organization, as well as ribosomal RNA synthesis. Specifically, it plays a role in repairing DNA double-strand breaks (DSBs) at replication forks during recovery from DNA damage. Furthermore, it regulates sister chromatid cohesion and mitotic chromosome segregation. DDX11 also stimulates the 5'-single-stranded DNA flap endonuclease activity of FEN1, independent of ATP and its helicase function. It contributes to heterochromatin organization and activates rRNA transcription by binding to hypomethylated rDNA gene loci, recruiting UBTF and RNA polymerase Pol I. This protein is also involved in embryonic development and associates with chromatin at DNA replication fork regions. Finally, DDX11 binds to both single- and double-stranded DNA.
Database Links
Protein Families
DEAD box helicase family, DEAH subfamily, DDX11/CHL1 sub-subfamily
Subcellular Location
Nucleus. Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle pole. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
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