LY86 antibodies are used in the immunodetection of the protein lymphocyte antigen 86. This protein is highly expressed in B-cells, monocytes, and tonsils. It plays a crucial role in mediating the innate immune response, particularly in cooperation with CD180 and TLR4, to respond to bacterial lipopolysaccharide (LPS) and cytokine production .
Protein Structure and Function: LY86 is a secreted protein with a reported length of 162 amino acid residues and a mass of 17.9 kDa. It undergoes post-translational modifications, including glycosylation .
Applications: LY86 antibodies are commonly used in Western Blot, ELISA, and Immunohistochemistry techniques for research purposes .
Species Reactivity: These antibodies are reactive with human proteins and have orthologs in various species such as mouse, rat, bovine, zebrafish, chimpanzee, and chicken .
LY86 is significant in identifying Unswitched Memory B Cells and Class Switched Memory B Cells. It is also known by synonyms such as MD1, MMD-1, dJ80N2.1, MD-1, RP105-associated protein MD-1 .
Characteristic | Description |
---|---|
Biological Source | Mouse |
Clone | 1H3 |
Species Reactivity | Human |
Technique(s) | Indirect ELISA, Western Blot |
Isotype | IgG2aκ |
Storage Temperature | -20°C |
KEGG: ath:AT5G48953
UniGene: At.63360