LCR47 Antibody
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In Stock 
Description
Clarification of Nomenclature
The term "LCR47" does not align with established naming conventions for antibodies. Antibodies are typically designated by:
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Target antigen (e.g., CD47)
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Clone number (e.g., Hu5F9-G4, B6H12)
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Developmental code (e.g., AK117, CC-90002)
Potential misinterpretations include:
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Typographical errors (e.g., "LCR47" vs. "CD47")
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Misreporting of clone names (e.g., CC2C6, M054)
Table 1: Key Anti-CD47 Antibodies in Development
Functional Outcomes
| Antibody Feature | Phagocytosis Enhancement | Hemagglutination Risk | Synergy with Opsonizing Antibodies |
|---|---|---|---|
| Hu5F9-G4 | Yes (AML/NHL) | High | Yes (rituximab, cetuximab) |
| AK117 | Yes (solid tumors) | None | Yes (AK112 anti-PD-1/VEGF) |
| CC-90002 | Moderate (AML/MDS) | Moderate | Limited |
Efficacy
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Hu5F9-G4: Achieved complete remission in 50% of NHL xenograft models when combined with rituximab .
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AK117: Reduced tumor volume by 80% in triple-negative breast cancer models (vs. 40% for monotherapy) .
Future Directions
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Components: 50% Glycerol, 0.01M Phosphate Buffered Saline (PBS), pH 7.4
Components: 50% Glycerol, 0.01M Phosphate Buffered Saline (PBS), pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
LCR47 antibody; At3g42473 antibody; T32A11Defensin-like protein 91 antibody; Low-molecular-weight cysteine-rich protein 47 antibody; Protein LCR47 antibody
Target Names
LCR47
Uniprot No.
Target Background
Database Links
Protein Families
DEFL family
Subcellular Location
Secreted.
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