ttm-5 Antibody
Description
Overview of TOMM5 Antibody
TOMM5 antibodies target the Translocase of Outer Mitochondrial Membrane 5 (TOMM5), a critical component of the TOM complex responsible for importing nuclear-encoded proteins into mitochondria . This single-pass membrane protein is conserved across eukaryotes and plays a role in maintaining mitochondrial function and cellular energy metabolism .
Mitochondrial Protein Import
TOMM5 is part of the TOM complex, which includes TOMM20, TOMM22, TOMM40, and TOMM70. This complex facilitates the translocation of preproteins into mitochondria .
Validation and Performance Data
Western Blot: Detects TOMM5 at expected molecular weights in mitochondrial lysates.
IHC/IF: Localizes TOMM5 to the mitochondrial outer membrane in human tissue samples .
Table 1: Antibody Performance Metrics
| Parameter | Specification |
|---|---|
| Specificity | Confirmed via peptide-blocking assays |
| Cross-reactivity | Human, mouse, rat (predicted) |
| Stability | Stable at 4°C for 6 months |
| Recommended Controls | Mitochondrial-enriched fractions |
Limitations and Future Directions
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Knowledge Gaps: Functional studies on TOMM5-specific roles in disease models are sparse.
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Validation Needs: Broader species cross-reactivity data and knockout validation are required.
Product Specs
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
