DEUP1 Antibody, FITC conjugated
Shipped with Ice Packs 
In Stock 
Product Specs
Buffer
**Preservative:** 0.03% Proclin 300
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Typically, we can ship your orders within 1-3 business days of receipt. Delivery times may vary depending on the purchase method and location. Please contact your local distributor for specific delivery information.
Synonyms
DEUP1 antibody; CCDC67 antibody; Deuterosome assembly protein 1 antibody; Coiled-coil domain-containing protein 67 antibody
Target Names
DEUP1
Uniprot No.
Target Background
Function
CCDC67 is a key structural component of the deuterosome, a structure responsible for promoting de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in fully differentiated multiciliated cells and can generate over 100 centrioles. CCDC67 is likely sufficient for the specification and formation of the deuterosome's inner core. It interacts with CEP152 and recruits PLK4 to activate centriole biogenesis.
Gene References Into Functions
- A single nucleotide polymorphism in the CCDC67 gene has been associated with Acute Renal Graft Rejection. PMID: 27272414
- Loss of CCDC67 expression is associated with papillary thyroid carcinoma. PMID: 26716505
- Research suggests that CCDC67 is a potential tumor suppressor gene that is silenced in gastric cancers by promoter CpG methylation. This silencing may play a significant role in cell signaling and migration related to tumorigenesis. PMID: 22610074
Database Links
Protein Families
CEP63 family
Subcellular Location
Cytoplasm.
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