BRR2A is an RNA helicase that plays a crucial role in pre-mRNA splicing. It is a component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes, participating in spliceosome assembly, activation, and disassembly.
Gene References Into Functions
BRR2A is essential for the efficient splicing of specific introns. These introns are characterized by a combination of factors including size, sequence, and chromatin context. The gene FLC exhibits particular sensitivity to BRR2A-related splicing defects. [PMID: 27100965](https://www.ncbi.nlm.nih.gov/pubmed/27100965)