LCR34 Antibody

Potential Nomenclature Errors

The term "LCR34" does not align with established antibody naming conventions. Closest matches from reviewed sources include:

Hypotheses for Discrepancy:

• Typographical error (e.g., "LCR" vs. "RAM" or "PCRP")

• Species-specific nomenclature not indexed in public databases

• Proprietary compound lacking published characterization

RAM34 (Anti-CD34)

• Structure: IgG2a, κ light chain

• Applications:

  • Identifies hematopoietic stem cells (7-10% of mouse bone marrow)

  • Binds capillary endothelial cells (spleen, thymus, lymph nodes)

  • Critical for isolating CD34+ Sca-1+ c-Kit+ progenitors

PCRP-CREB3L4-1A3

• Structure: Mouse IgG2b

• Target: Human CREB3L4 transcription factor

• Validation Data:

Validation Methodologies

For uncharacterized antibodies like LCR34, standard validation workflows would include:

1. Epitope Mapping

   • Phage display or crystallography (as in )

2. Functional Assays

   • Neutralization potency (e.g., HBV/HDV models in )

3. Cross-Reactivity Profiling

   • Protein arrays (NCI60 panel in )

Recommendations for Further Research

1. Verify the antibody's correct nomenclature with originating laboratory.

2. Perform mass spectrometry to confirm amino acid sequences if physical samples exist.

3. Submit negative results to databases like Antibody Registry to prevent duplication.