DGCR8 Antibody

1. Heme is essential for the Microprocessor complex to accurately process pri-miRs. PMID: 29170488
2. The AG genotype in rs3757 DGCR8 exhibits a protective effect against primary open angle glaucoma, whereas the GG homozygote is likely associated with an increased risk of glaucoma. PMID: 29912490
3. La protein is a critical component of the microprocessor complex, regulating miRNA processing efficiency by associating with DGCR8 to regulate the formation of the DGCR8-Drosha complex for miRNA processing. PMID: 29087193
4. This study unveils an unexpected function of DGCR8 in the repair of UV-induced DNA lesions, independent of miRNA processing. PMID: 28380355
5. BRG1 and SMARCAL1, members of the ATP-dependent chromatin remodeling family, co-regulate the transcription of DROSHA, DGCR8, and DICER in response to double-strand DNA breaks. PMID: 28716689
6. NEAT1 broadly interacts with the NONO-PSF heterodimer and numerous other RNA-binding proteins. Multiple RNA segments in NEAT1, including a 'pseudo pri-miRNA' near its 3' end, attract the Drosha-DGCR8 Microprocessor. PMID: 28846091
7. Data suggest a model where the bis-cysteine thiolate ligand environment of Fe(III) DGCR8 is crucial for establishing proper pri-miRNA binding and enabling processing activity. PMID: 27766492
8. The rs417309 and rs1640299 polymorphisms of the DGCR8 gene, as well as rs6877842 of the DROSHA gene, may be associated with an increased risk of laryngeal cancer occurrence in the Polish population. PMID: 28155978
9. Studies support the retention of DGCR8 cysteine coordination upon reduction, a conclusion differing from previous studies of a different ferrous DGCR8 isoform. PMID: 27546061
10. Drosha and DGRC8 were significantly downregulated in healthy-appearing perilesional skin from hidradenitis suppurativa patients compared to healthy controls. PMID: 26917346
11. DENV4 infection exhibited the highest viral load 3 days post-infection. Dicer, Drosha, and DGCR8 showed reduced expression following DENV4 infection compared to negative controls. PMID: 27173348
12. DGCR8 is significantly upregulated in invasive ductal breast carcinoma, suggesting a fundamental role for its increased expression during breast carcinogenesis. PMID: 26804549
13. DGCR8 and Drosha assemble into a heterotrimeric complex on RNA, comprising two DGCR8 molecules and one Drosha molecule. PMID: 26683315
14. DGCR8 forms an alternative complex with the RRP6-containing form of the exosome, acting as an adaptor to recruit the exosome to target structured RNAs. The DGCR8/hRRP6 complex controls the stability of human telomerase RNA. PMID: 26687677
15. This study evaluated the expression of key components of the microRNA biogenesis machinery, including Drosha, Dicer, and DiGeorge syndrome critical region gene 8 (DGCR8), in multiple sclerosis patients. PMID: 25439752
16. This research reveals a novel pathway in the DNA damage response where ABL-dependent tyrosine phosphorylation of DGCR8 stimulates the processing of specific primary miRNAs. PMID: 26126715
17. DGCR8 acts as an oncogene in ovarian cancer, partially mediated by miR-27b. PMID: 25823356
18. Together with a 23-amino acid peptide from DGCR8, DROSHA constitutes a minimal functional core. DROSHA acts as a "ruler" by measuring 11 bp from the basal ssRNA-dsRNA junction. DGCR8 interacts with the stem and apical elements through its dsRNA-binding domains and RNA-binding heme domain, respectively, facilitating efficient and accurate processing. PMID: 26027739
19. Data indicate decreased DGCR8 expression and miRNA dysregulation in individuals with 22q11.2 deletion syndrome. PMID: 25084529
20. Hepatitis B virus proteins repress DGCR8 promoter activity by upregulating the expression of transcription factor YY1. PMID: 25427980
21. Tumors with DGCR8 E518K and DROSHA exon 29 (miRNAPG-HS) mutations exhibit a higher prevalence of tumors with blastemal predominant histology in patients with miRNAPG-HS and/or SIX1/2 Q177R mutations. PMID: 25670082
22. Recurrent mutations include a hotspot mutation (Q177R) in the homeo-domain of SIX1 and SIX2 in tumors with high proliferative potential (18.1% of blastemal cases); mutations in the DROSHA/DGCR8 microprocessor genes. PMID: 25670083
23. This study reveals a unique protein-RNA interaction central to pri-miRNA recognition. Two DGCR8 dimers clamp a pri-miRNA hairpin using their Rheds. PMID: 24910438
24. This study demonstrated for the first time that the DGCR8 mRNA expression level was up-regulated in colorectal carcinomas, suggesting its important role in the pathobiology of colorectal carcinogenesis. PMID: 23775303
25. Multisite phosphorylation regulates DGCR8 protein stability, increasing microprocessor complex levels, altering the mature miRNA profile of the cell, and enhancing cell proliferation and migration. PMID: 24239349
26. The Microprocessor complex of Drosha and DGCR8 proteins, responsible for processing primary transcripts during microRNA generation, destabilizes the mRNA of Aurora kinase B. PMID: 24589731
27. A subset of senescence-associated miRNAs with the potential to target p21CIP1 is downregulated during DGCR8-mediated senescence. PMID: 23773483
28. This research reveals a role for DeltaNp63 in the transcriptional regulation of DGCR8 to reprogram adult somatic cells into multipotent stem cells. PMID: 24449888
29. DGCR8 is a miRNA processing enzyme and is altered in non-alcoholic fatty liver disease. PMID: 23663110
30. Specific RNA processing is likely facilitated by preformed DGCR8-Drosha heterodimers that can discriminate between authentic substrates and other hairpins. PMID: 23893406
31. The RNase III enzyme Drosha and the double-stranded RNA-binding protein DGCR8 bind and regulate a large variety of cellular RNAs. PMID: 23863141
32. Single nucleotide polymorphisms in the DGCR8 3'-UTR that binds to miR-106b/miR-579 are associated with breast cancer. PMID: 23629745
33. DGCR8, AGO1, AGO2, PACT, and TARBP1 expression levels were significantly higher in the epithelial skin cancer groups than the healthy controls (P > 0.05). PMID: 22025453
34. DGCR8 and Drosha are targeted post-transcriptionally to chromosome 19 microRNA cluster pri-miRNAs as a preformed complex but dissociate separately. PMID: 22393237
35. DGCR8-mediated cleavage of snoRNAs was independent of Drosha, suggesting the involvement of DGCR8 in cellular complexes with other endonucleases. Binding of DGCR8 to cassette exons is a novel mechanism for regulating alternatively spliced isoforms. PMID: 22796965
36. DGCR8 is cleaved by caspases between Asp396 and Ser397 in HeLa cells. PMID: 22434730
37. HDAC1 is an integral component of the Drosha/DGCR8 complex and enhances miRNA processing by increasing DGCR8 affinity to primary miRNA transcripts via deacetylation of critical lysine residues in DGCR8's RNA-binding domains. PMID: 22222205
38. This study demonstrates the binding specificity of DGCR8 for ferric heme, providing direct biochemical evidence for ferric heme serving as an activator for miRNA maturation. PMID: 22308374
39. This study analyzes the function of the DGCR8-heme interaction in microRNA maturation. PMID: 21454614
40. The mRNA for the microprocessor component DGCR8 was found to be significantly upregulated in the dorsolateral prefrontal cortex and superior temporal gyrus in tissues from schizophrenic patients. PMID: 19721432
41. The dimerization domain of DGCR8 is embedded within an independently folded heme-binding domain and directly contributes to heme association. Heme-binding-deficient DGCR8 mutants exhibit reduced pri-miRNA processing activity in vitro. PMID: 20506313
42. SRY is a hybrid of DGCR8 and SOX3, regulated by the transcription factor CP2. PMID: 19902333
43. The Microprocessor, containing the RNA-binding protein Dgcr8 and RNase III enzyme Drosha, is responsible for processing primary microRNAs to precursor microRNAs. PMID: 19759829
44. Molecular cloning and expression analysis of DGCR8. PMID: 12705904
45. DGCR8 may be an essential component of the primary miRNA processing complex, along with Drosha. PMID: 15574589
46. DGCR8 is required for the maturation of miRNA primary transcripts. PMID: 15589161
47. DGCR8 may function as the molecular anchor that measures the distance from the dsRNA-ssRNA junction. PMID: 16751099
48. The RNA-binding protein DiGeorge critical region-8 (DGCR8), essential for the initial step of miRNA processing, is a heme-binding protein. Heme association promotes DGCR8 dimerization. PMID: 17159994
49. DGCR8 core recognizes pri-miRNA in two possible orientations. A model for DGCR8's recognition of pri-miRNA is proposed. PMID: 17704815
50. DGCR8 is located at the nucleolus and small foci adjacent to splicing speckles in the nucleoplasm. PMID: 17765891

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HGNC: 2847

OMIM: 609030

KEGG: hsa:54487

STRING: 9606.ENSP00000263209

UniGene: Hs.643452