DIR2 Antibody

DIRAS2 Antibody Overview

DIRAS2 antibodies are laboratory tools designed to detect and study the DIRAS2 protein (UniProt: Q96HU8), which plays roles in GTPase-mediated signaling. These antibodies are widely used in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF/ICC) to investigate DIRAS2 expression and function in human, mouse, and rat tissues .

Product Data

Research Applications

• Western Blotting: Validated for detecting DIRAS2 in lysates from human, mouse, and rat samples .

• Immunofluorescence: Used to localize DIRAS2 in cell lines, with protocols optimized for paraffin-embedded and frozen sections .

• Functional Studies: DIRAS2’s GTPase activity and role in RAS signaling pathways are under investigation, though direct mechanistic studies using these antibodies are not detailed in the provided sources .

Limitations and Notes

• Species Reactivity: While reactivity with human, mouse, and rat is confirmed, predictions for pig, bovine, and dog remain unvalidated .

• Epitope Information: The exact binding epitope of these antibodies is unspecified, which may limit their utility in certain experimental designs .

• Research Context: Current literature focuses on DIRAS2’s structural and functional similarities to other Ras-family GTPases, but targeted studies using DIRAS2 antibodies are scarce .