polb Antibody
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Product Specs
Target Background
Function
Pol β is a repair polymerase that plays a crucial role in base-excision repair. It possesses 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity, enabling it to remove the 5' sugar phosphate. Additionally, Pol β functions as a DNA polymerase, adding a single nucleotide to the 3' end of the resulting single-nucleotide gap. Its DNA synthesis during 'gap-filling' occurs in a stepwise distributive manner, distinct from the processive nature observed in other DNA polymerases.
Database Links
STRING: 7955.ENSDARP00000017489
UniGene: Dr.116025
Protein Families
DNA polymerase type-X family
Subcellular Location
Nucleus. Cytoplasm.
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