CPEFG Antibody
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Product Specs
Buffer
Preservative: 0.03% ProClin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
14-16 weeks (Made-to-order)
Synonyms
CPEFG antibody; SCO1 antibody; At1g62750 antibody; F23N19.11Elongation factor G antibody; chloroplastic antibody; cEF-G antibody; Elongation factor EF-G/SCO1 antibody; Protein SNOWY COTYLEDON 1 antibody; chloroplastic antibody; AtSCO1 antibody
Target Names
CPEFG
Uniprot No.
Target Background
Function
This antibody targets chloroplast-localized elongation factor G (EF-G), a crucial protein in plastid protein synthesis. EF-G catalyzes the GTP-dependent ribosomal translocation step during translation elongation. This involves the movement of the ribosome from the pre-translocational (PRE) to the post-translocational (POST) state. Specifically, the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. EF-G catalyzes the coordinated movement of these tRNAs, the mRNA, and associated conformational changes within the ribosome. It is also essential for the redifferentiation of eoplasts into chloroplasts following germination.
Gene References Into Functions
The function of this protein is further supported by the following research:
1. The *SCO1* gene encodes the chloroplast-localized elongation factor G. Mutations in *SCO1* (also known as *AtSCO1*) impair chloroplast mRNA translation. [snowy cotyledon 1] (PMID: 16525888)
2. Seedlings with mutant *SCO1* alleles exhibit cotyledon and hypocotyl albinism due to defective chloroplast development. These seedlings typically die shortly after germination, highlighting the essential role of SCO1 in plant growth. (PMID: 17629920)
Database Links
Protein Families
TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-G/EF-2 subfamily
Subcellular Location
Plastid, chloroplast.
Tissue Specificity
Expressed in cotyledons and at lower levels in adult leaves.
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