ELF3 Antibody, FITC conjugated

1. ELF3 was shown to form a positive feedback loop with MAPK pathways. PMID: 30365150
2. Low ESE1 expression is associated with Non-Small Cell Lung Cancer (NSCLC). PMID: 30015943
3. Research suggests that ELF3 is upregulated at the mRNA and protein levels in NSCLC tissues compared to control lung tissue. The expression level of ELF3 correlates with the overall survival of patients with NSCLC. PMID: 29208568
4. Leptin acts synergistically with IL-1beta to induce ELF3 expression in chondrocytes. PMID: 29550824
5. Data demonstrate the direct binding of miR-320a-3p on the 3'UTR region of ELF3 mRNA in non-small cell lung cancer cells, causing transcriptional downregulation of ELF3 expression. PMID: 29803922
6. Data suggest that ESE-1 silencing may be a viable therapeutic approach for HER2(+) patients who exhibit resistance to anti-HER2 therapy. PMID: 29187433
7. These findings position RIPK4 upstream of a hierarchical IRF6-GRHL3-ELF3 transcription factor pathway in keratinocytes. PMID: 27667567
8. Epithelium-specific ETS transcription factor 1 (ESE1) is a member of the Ets transcription factor family. PMID: 28247944
9. ELF3 interacts directly with the HMG domain of Sox9. Significantly, overexpression of ELF3 leads to a marked decrease in Sox9/CBP-dependent HAT activity. PMID: 27310669
10. Data indicate that the transcription factor E74-like factor 3 (ELF3) is one of the genes whose expression is upregulated in microdissected ovarian cancer cells of long-term survivors. PMID: 28199976
11. ELF3 is a frequently mutated tumor suppressor gene of periampullary tumors. PMID: 26804919
12. ELF3 is a novel transcriptional repressor of estrogen receptor alpha in breast cancer cells. PMID: 26920025
13. Research suggests that ESE-1 may play a role in regulating airway inflammation by modulating ICAM-1 expression. PMID: 26185364
14. Data indicate that ESE1/ELF3 may promote ulcerative colitis (UC) progression by accelerating NF-kappaB activation and thus facilitating intestinal epithelial cell apoptosis. PMID: 25926267
15. Findings indicate that polyomavirus enhancer activator 3 and epithelium-specific transcription factor-1 may play important roles in pluripotent and tumorigenic embryonic carcinoma cells. PMID: 24694612
16. Data identify Elf3 as a pivotal driver for beta-catenin signaling in colorectal cancer (CRC), highlighting the potential prognostic and therapeutic significance of Elf3 in CRC. PMID: 24874735
17. ESE-1 acts as an upstream effector to regulate OCT4 transcription in NCCIT pluripotent embryonic carcinoma cells. PMID: 24971534
18. The physical interaction between ELF3 and androgen receptor (AR) inhibits the recruitment of AR to specific androgen response elements within target gene promoters. PMID: 23435425
19. ELF3 is a candidate transcriptional regulator involved in human urothelial cytodifferentiation. PMID: 24374157
20. The concordant upregulation of ESE1/ELF3 and NF-kappaB in human prostate tumors is observed. PMID: 23687337
21. Frequent copy number gains at 1q21 and 1q32 are associated with overexpression of the ETS transcription factors ETV3 and ELF3 in breast cancer irrespective of molecular subtypes. PMID: 23329352
22. ELF3 and CEA expression show statistically significant differences among four lymph node groups: lymph nodes from patients with colorectal cancer categorized into three Dukes' stages and LNs from patients with ulcerative colitis. PMID: 22993316
23. A novel role for ELF3 as a procatabolic factor is suggested, potentially contributing to cartilage remodeling and degradation by regulating MMP13 gene transcription. PMID: 22158614
24. ESE-1 contains signal sequences that play a critical role in regulating its subcellular localization and function. An intact SAR domain mediates mammary epithelial cell transformation exclusively in the cytoplasm. PMID: 21871131
25. ErbB2 activation of ESX gene expression has been observed. PMID: 12032832
26. ESX regulates HER2 expression by binding to DRIP130. PMID: 12242338
27. Coordinated activation and binding of ESE-1, Sp1, and NF-kappaB to the MIP-3alpha promoter is required for maximal gene expression by cytokine-stimulated Caco-2 human intestinal epithelial cells. PMID: 12414801
28. Ese-1 binds with Skn-1a in human cells. PMID: 12624109
29. ERT mediates the expression of TGF-beta RII, and the transcriptional inhibition of ets-related transcription factor could be one of the mechanisms of colonic carcinogenesis. PMID: 14582709
30. Results support a role for the ETS factor ESE-1 as a novel transcriptional regulator of angiopoietin-1 gene regulation in the context of inflammation. PMID: 14715662
31. ESX expression alone confers a transformed and in vitro metastatic phenotype to otherwise normal MCF-12A cells. PMID: 14767472
32. Stably expressed green fluorescent protein-ESE-1 transforms MCF-12A human mammary epithelial cells; the ESE-1 SAR domain, acting in the cytoplasm, is necessary and sufficient to mediate this transformation. PMID: 15169914
33. The induction of claudin7 expression by ELF3 appears critical to the formation of the epithelial structures in biphasic synovial sarcoma. PMID: 17060315
34. The AT-hook domain, as well as the serine- and aspartic acid-rich domain, but not the pointed domain, is necessary for Elf3 activation of promoter activity. PMID: 17148437
35. ESE-1 functions are coordinately regulated by Pak1 phosphorylation and beta-TrCP-dependent ubiquitin-proteasome pathways. PMID: 17491012
36. Intracellular ESE-1 staining in chondrocytes in cartilage from patients with osteoarthritis, but not in normal cartilage, further suggests a fundamental role for ESE-1 in cartilage degeneration and suppression of repair. PMID: 18044710
37. ESE-1 negatively regulates the invasion of oral squamous cell carcinoma via transcriptional suppression of MMP-9. PMID: 18302674
38. ESE-1 and ESE-3 play an important role in airway inflammation. PMID: 18475289

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HGNC: 3318

OMIM: 602191

KEGG: hsa:1999

STRING: 9606.ENSP00000352673

UniGene: Hs.603657