EPHA8 Antibody
Shipped with Ice Packs 
In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Typically, we can ship your orders within 1-3 business days after receiving them. Delivery times may vary depending on the order method or location. Please consult your local distributor for specific delivery time information.
Synonyms
EPHA8 antibody; EEK antibody; HEK3 antibody; KIAA1459Ephrin type-A receptor 8 antibody; EC 2.7.10.1 antibody; EPH- and ELK-related kinase antibody; EPH-like kinase 3 antibody; EK3 antibody; hEK3 antibody; Tyrosine-protein kinase receptor EEK antibody
Target Names
EPHA8
Uniprot No.
Target Background
Function
EphA8 is a receptor tyrosine kinase that binds promiscuously to GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling between neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling, while the signaling pathway downstream of the ephrin ligand is known as reverse signaling. The GPI-anchored ephrin-A family members EFNA2, EFNA3, and EFNA5 are capable of activating EPHA8 through phosphorylation. EPHA8, in conjunction with EFNA5, may regulate integrin-mediated cell adhesion and migration on fibronectin substrates, as well as neurite outgrowth. During the development of the nervous system, EPHA8 also plays a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN, which promotes cell adhesion upon activation by EPHA8, and the MAP kinases, which are involved in the stimulation of neurite outgrowth.
Gene References Into Functions
- Quantitative PCR (Q-PCR) and immunohistochemistry (IHC) staining revealed that EphA8 was highly expressed in oral tongue squamous cell carcinoma (OTSCC) tissues, particularly in advanced-stage OTSCC tissues. Kaplan-Meier curve analysis indicated that high EphA8 expression was significantly associated with poor prognosis. PMID: 30300334
- High EPHA8 expression has been linked to epithelial ovarian cancer. PMID: 26989075
- Human miR-10a and EphA8 regulate epithelial-mesenchymal transition (EMT) to affect glioma cell migration and invasion. PMID: 25683004
- RINL, a guanine nucleotide exchange factor (GEF) for the Rab5 subfamily, is implicated in the EphA8 degradation pathway through its interaction with odin. PMID: 22291991
- EPHA8 plays a role in stimulated cell migration in the presence of p110 gamma PI-3 kinase. PMID: 12681484
- The EphA8 receptor is capable of inducing a sustained increase in MAPK activity, thereby promoting neurite outgrowth in neuronal cells. PMID: 15782114
Database Links
Protein Families
Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell projection. Early endosome membrane.
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