ERF014 Antibody
Description
Introduction to Antibodies
Antibodies are Y-shaped proteins produced by B cells that play a crucial role in the immune system by binding to specific antigens, such as bacteria, viruses, or other pathogens . They are essential for identifying and neutralizing foreign substances, thereby protecting the body from infections.
Types of Antibodies
There are five main types of antibodies: IgG, IgA, IgM, IgE, and IgD. Each type has distinct functions and locations within the body . For example, IgG is the most common antibody in blood circulation and provides long-term immunity against infections.
Monoclonal Antibodies
Monoclonal antibodies are produced in laboratories and are designed to target specific antigens. They are used in treatments for infections, cancers, and autoimmune diseases . Recent advancements include the development of bispecific antibodies that can target multiple antigens simultaneously, enhancing therapeutic efficacy .
Applications of Antibodies in Research and Medicine
Antibodies are used extensively in medical research and treatment. For instance, monoclonal antibodies like VIR-3434 are being investigated for their potential in treating chronic hepatitis B and D by neutralizing viral particles . Additionally, bispecific antibodies targeting EGFR and EPHA2 have shown promise in cancer therapy by inhibiting tumor growth more effectively than traditional treatments .
Challenges in Antibody Research
Despite the progress in antibody technology, challenges remain, such as developing antibodies that can overcome drug resistance in cancer treatment . Researchers are employing novel strategies to identify optimal target combinations for bispecific antibodies, which could improve treatment outcomes .
Future Directions
The future of antibody research involves continued innovation in designing more effective and targeted therapies. This includes developing new methods for predicting optimal co-targets for bispecific antibodies and exploring their potential in various diseases .
Since specific data on "ERF014 Antibody" could not be found, the following table provides a general overview of some notable antibodies and their applications:
| Antibody/Compound | Target | Application | Status |
|---|---|---|---|
| VIR-3434 | HBV, HDV | Chronic Hepatitis B and D treatment | Preclinical/Clinical trials |
| Anti-EGFR/EPHA2 | EGFR, EPHA2 | Cancer therapy | Preclinical |
| VRC01 | HIV | HIV prevention | Clinical trials |
Product Specs
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Target Background
- AtERF014 exhibits dual regulatory activity, modulating immunity against Pseudomonas syringae pv. tomato (Pst) and Botrytis cinerea (Bc) in Arabidopsis thaliana. [PMID: 27445230](https://www.ncbi.nlm.nih.gov/pubmed/27445230)
- ERF gene overexpression coordinately activates pectin biosynthetic pathway genes, resulting in increased pectin content. [PMID: 22160296](https://www.ncbi.nlm.nih.gov/pubmed/22160296)
