Function
EARLI1 is a probable lipid transfer protein (LTP) that may enhance freezing survival. Evidence suggests it plays a role in regulating flowering and lignin biosynthesis. Furthermore, it contributes to germination and early seedling development under low temperature and salt stress conditions, possibly through an abscisic acid (ABA)-dependent mechanism. EARLI1 confers resistance to *Botrytis cinerea* and exhibits antifungal activity against *Saccharomyces cerevisiae*, *B. cinerea*, and *Fusarium oxysporum*, potentially by increasing membrane permeability.
Gene References Into Functions
- Subcellular localization studies indicate EARLI1 is found in locations consistent with lipid exchange/movement (PMID: 26203923).
- In vivo expression of secreted EARLI1 in *S. cerevisiae* significantly inhibited yeast cell growth (PMID: 22759515).
- A proposed bimodular architecture for EARLI1 suggests its proline-rich domain interacts with the cell wall, while the 8CM domain interacts with the plasma membrane to protect cells during freezing stress (PMID: 17786468).
Protein Families
Plant LTP family, PEARLI1 subfamily
Subcellular Location
Secreted, cell wall.
Tissue Specificity
Mostly expressed in aerial part of seedlings, and, to a lower extent, in roots. Higher basal levels in early-flowering ecotypes.