ESX1 Antibody
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In Stock 
Product Specs
Buffer
Phosphate Buffered Saline (PBS) with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid repeated freeze-thaw cycles.
Lead Time
Typically, we can ship the products within 1-3 business days after receiving your orders. Delivery time may vary depending on the shipping method and destination. Please consult your local distributors for specific delivery timeframes.
Synonyms
ESX1 antibody; ESX1L antibody; ESX1R antibody; Homeobox protein ESX1 antibody; Extraembryonic antibody; spermatogenesis antibody; homeobox 1) [Cleaved into: Homeobox protein ESX1-N; Homeobox protein ESX1-C] antibody
Target Names
Uniprot No.
Target Background
Function
ESX1 antibody may play a role in regulating cell cycle progression and transcription during spermatogenesis. It inhibits the degradation of polyubiquitinated cyclin A and cyclin B1, thereby arresting the cell cycle in early M phase. ESXR1-N acts as a transcriptional repressor. It binds to the sequence 5'-TAATGTTATTA-3', which is found within the first intron of the KRAS gene, and inhibits its expression. ESXR1-C has the capability to inhibit cyclin turnover.
Gene References Into Functions
- ESX1 mRNA levels decrease as the severity of spermatogenic defects increases in men with non-obstructive azoospermia. PMID: 25316452
- ESX1 emerges as a potentially reliable molecular marker for residual spermatogenesis in azoospermic men. PMID: 20356899
- Proteolytic processing of ESXR1 plays a role in the coordinated regulation of the cell cycle and transcription in human cells. PMID: 15235584
- ESX1L is expressed during all stages of placental development and is localized to sparse areas of trophoblast in terminal villi in association with cytotrophoblastic cells. PMID: 15601583
- In FGR-affected placentae, ESX1L levels were lower than in gestation-matched controls, indicating a potential role for the ESX1L gene in the growth control mechanism of the fetus, through its effect on placental function. PMID: 16613891
Database Links
Subcellular Location
Cytoplasm. Nucleus. Note=ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm.
Tissue Specificity
Expressed in placenta and testis. Expressed in testicular germ cell tumors.
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