ESYT1 Antibody
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (12-14 weeks)
Synonyms
E Syt1 antibody; E-Syt1 antibody; Esyt1 antibody; ESYT1_HUMAN antibody; Extended synaptotagmin 1 antibody; Extended synaptotagmin like protein 1 antibody; Extended synaptotagmin-1 antibody; FAM62A antibody; Family with sequence similarity 62 (C2 domain containing) member A antibody; Family with sequence similarity 62 member A antibody; KIAA0747 antibody; MBC2 antibody; Membrane bound C2 domain containing protein antibody; Membrane-bound C2 domain-containing protein antibody; Protein FAM62A antibody
Target Names
ESYT1
Uniprot No.
Target Background
Function
ESYT1 antibody binds glycerophospholipids within a barrel-like domain, potentially playing a role in cellular lipid transport. It binds calcium through its C2 domains and translocates to sites where the endoplasmic reticulum meets the cell membrane in response to elevated cytosolic calcium levels. ESYT1 antibody contributes to tethering the endoplasmic reticulum to the cell membrane and promotes the formation of junctions between these two structures.
Gene References Into Functions
- Calcium's primary effect on E-Syt1 is to reverse an autoinhibited state, coupling membrane tethering with lipid transport. PMID: 29222176
- Knockdown of ESYT1 (and its family members ESYT2 and ESYT3) significantly reduced ANO1 current density. PMID: 29154949
- This study identified and confirmed alterations in ESYT1 protein within the postsynaptic density in schizophrenia. PMID: 25048004
- ESyt2 and ESyt3, unlike ESyt1, interact with activated FGFR1. PMID: 25922075
- The extended synaptotagmins (E-Syt1, E-Syt2, and E-Syt3) are endoplasmic reticulum-anchored proteins. They form homo- and heteromeric complexes that mediate interactions with the plasma membrane. These interactions are highly dependent on the presence of PI(4,5)P2 in the membrane and are further regulated by cytosolic Ca2+ through the calcium-sensing properties of E-Syt1. PMID: 23791178
- E-Syt1 acts as a mediator of cancer cell invasion. PMID: 22659450
Database Links
Protein Families
Extended synaptotagmin family
Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Peripheral membrane protein.
Tissue Specificity
Widely expressed.
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