EVL Antibody
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In Stock 
Product Specs
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. Stored at -20°C. Avoid freeze/thaw cycles.
Lead Time
Typically, we can ship your order within 1-3 business days of receipt. Delivery times may vary depending on your location and shipping method. Please consult your local distributor for specific delivery details.
Synonyms
EVL antibody; RNB6Ena/VASP-like protein antibody; Ena/vasodilator-stimulated phosphoprotein-like antibody
Target Names
EVL
Uniprot No.
Target Background
Function
Ena/VASP proteins are actin-associated proteins that play a crucial role in various processes involving cytoskeleton remodeling and cell polarity, such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization.
Gene References Into Functions
- EVL/miR-342 methylation was preferentially detected in IgD multiple myeloma. PMID: 29242101
- CRMP-1 has been identified as a novel regulator of actin filament elongation, highlighting the critical role of CRMP-1, EVL, and actin polymerization in maintaining the structural integrity of epithelial sheets. PMID: 28630144
- ENA/VASP-family proteins demonstrate functional redundancy in homologous recombination, and MENA, VASP, and EVL are potentially involved in the DSB repair pathway in humans. PMID: 21398369
- EVL, in combination with either E. coli topoisomerase I or human topoisomerase IIIalpha, has been shown to catalyze ssDNA catenation. PMID: 20639531
- Ena/VASP proteins regulate actin polymerization at actin filament barbed ends in vitro, both in the presence and absence of barbed end capping proteins. PMID: 15939738
- Research has investigated the interaction of the alphaII-spectrin SH3 domain with EVL. PMID: 16336193
- Evidence suggests that ena/VASP binding to F-actin facilitates the recruitment of gephyrin to the leading edge of uncapped actin filaments. PMID: 16376568
- EVL has been found to be essential for endothelial barrier function in vivo. PMID: 17998398
- A microRNA encoded within an intron of the EVL gene is frequently suppressed in human colorectal cancer. PMID: 18264139
- EVL may play a role in the invasion and/or metastasis of human breast cancer. PMID: 18357390
- EVL protein is a novel recombination factor that may be essential for repairing specific DNA lesions, and its inappropriate expression may contribute to tumor malignancy. PMID: 19329439
- The EVH2 domain, which is highly conserved among the ENA/VASP family proteins, may be responsible for the recombination function of EVL. PMID: 19725871
Database Links
Protein Families
Ena/VASP family
Subcellular Location
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cell projection, lamellipodium.
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