MOD1 Antibody

MOD1 Antibody in Plant Biology

MOD1 (Arabidopsis thaliana) is an enoyl-[acyl-carrier-protein] reductase [NADH] involved in fatty acid biosynthesis and chloroplast function. The Mouse Anti-MOD1 Antibody (CBMOAB-36632FYC) is a research tool developed to detect this protein:

MOD1 in Antibody Engineering

In Lyme disease research, DMAb Mod1 refers to a modified DNA-encoded monoclonal antibody targeting Borrelia burgdorferi’s outer surface protein A (OspA). Key modifications include:

• Framework optimization to enhance expression (2.5× higher in vitro than the wild-type variant) .

• Dose-dependent efficacy: Administered at 100–300 µg in mice, achieving serum concentrations of 5.7–6.7 µg/mL.

In Vivo Performance

DMAb Mod1 reduced Borrelia transmission in 75%–77% of mice post-tick challenge, demonstrating its potential as a prophylactic .

MOD1 in Epitope-Specific Antibody Development

The Epivolve protocol uses mod1, a synthetic amino acid modification, to direct antibodies toward specific epitopes. This approach:

• Avoids immune tolerance by using in vitro phage display .

• Enables targeting of non-immunogenic sites (e.g., single-residue mutations in cancer or neurodegenerative proteins) .

For example, α-miSOD1 antibodies targeting misfolded superoxide dismutase 1 (SOD1) in ALS:

• Reduced SOD1 aggregates by 40%–60% in transgenic mice .

• Extended survival by 2 months in SOD1-G93A murine models .

Therapeutic Optimization Strategies

While not specific to MOD1, antibody engineering principles apply broadly:

• Fc modifications (e.g., YTE or LS mutations) enhance half-life (4–5× in humans) .

• Glycoengineering modulates effector functions like ADCC and CDC .