FAO1 Antibody
Description
Antibody Structure and Function
Antibodies are Y-shaped proteins comprising two heavy chains and two light chains, with distinct Fab (antigen-binding) and Fc (effector) regions . Their specificity and efficacy depend on:
Antibody Validation Challenges
Recent studies emphasize the importance of rigorous antibody characterization:
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Ayoubi et al. (2023) tested 614 antibodies and found that ~50% of commercial antibodies failed to recognize their targets in critical assays (e.g., Western blot, immunofluorescence) .
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Recombinant antibodies outperformed monoclonal/polyclonal variants in specificity and consistency .
Approved Therapeutic Antibodies
The Antibody Society database lists over 1,000 approved or investigational antibodies, none of which reference "FAO1" . For example:
| Antibody | Target | Class | Applications |
|---|---|---|---|
| TAVO103A | IL-1β | Humanized IgG1 | Autoinflammatory diseases |
| Loncastuximab tesirine | CD19 | Humanized IgG1 ADC | Diffuse large B-cell lymphoma |
Recommendations for Further Investigation
To resolve the ambiguity surrounding FAO1 Antibody:
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Verify Nomenclature: Confirm the antibody’s official name or accession code (e.g., UniProt, GenBank).
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Consult Proprietary Databases: Reach out to biotech companies or research institutions for unpublished data.
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Search Preprint Servers: Platforms like bioRxiv or medRxiv may host preliminary studies.
Product Specs
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Target Background
KEGG: ath:AT1G03990
STRING: 3702.AT1G03990.1
