FAX2 Antibody

FOXC2 Antibody Overview

FOXC2 (Forkhead Box Protein C2) is a transcription factor implicated in mesenchymal tissue development, lymphangiogenesis, and cancer metastasis . The FOXC2 Antibody (OAAB07825) targets a phosphorylated epitope (P198) in its central region:

FOXC2 antibodies are used to study triple-negative breast cancer and angiosarcoma, where FOXC2 overexpression correlates with tumor aggressiveness . In preclinical models, FOXC2 inhibition reduced tumor growth by 52–58% .

FOXK2 Antibody Overview

FOXK2 (Forkhead Box K2) regulates metabolic pathways, DNA repair, and cancer cell proliferation. The FOXK2 Antibody #12008 (Cell Signaling Technology) is widely used for detection:

FOXK2 antibodies have been employed in studies linking its expression to chemotherapy resistance in colorectal cancer .

Comparative Functional Roles

Research Applications

• FOXC2:

  • Validated in MDA-MB-231 xenografts, showing 52% tumor reduction .

  • Used to investigate lymphovascular invasion in melanoma .

• FOXK2:

  • Detects post-translational modifications in mTOR pathway studies .

  • Identified as a biomarker for oxidative stress responses .

Technical Considerations

• Cross-Reactivity: FOXC2 antibodies may show weak reactivity with FOXD3 due to conserved forkhead domains .

• Validation: FOXK2 antibodies require verification via knockout cell lines to rule off-target binding .

Emerging Therapeutic Relevance

FOXC2 is being explored in antibody-drug conjugates (ADCs) targeting tissue factor (TF) in heterogeneous tumors . FOXK2 modulation is under investigation for enhancing chemosensitivity in glioblastoma .