At3g19410 Antibody

Introduction to At3g19410 Antibody

The At3g19410 antibody is a specialized immunological reagent designed to detect and study the Arabidopsis thaliana protein encoded by the AT3G19410 gene. This gene is annotated as a Kelch repeat F-Box protein (KFP), a class of proteins involved in ubiquitin-mediated protein degradation pathways . F-box proteins typically act as substrate receptors in SCF (SKP1-CUL1-F-box) E3 ubiquitin ligase complexes, targeting specific proteins for degradation . The At3g19410 antibody serves as a critical tool for investigating the protein’s localization, interaction partners, and functional roles in plant biology.

Target Protein Classification

• Gene ID: AT3G19410

• Protein Family: Kelch repeat F-Box protein (KFP)

• Domain Features:

  • F-box domain: Mediates interaction with core SCF complex components (e.g., SKP1, CUL1) .

  • Kelch repeats: Likely involved in substrate recognition or protein-protein interactions .

Applications in Research

The At3g19410 antibody enables:

Current Knowledge Gaps

• Limited direct studies: No peer-reviewed publications explicitly detail At3g19410’s role.

• Functional redundancy: Overlap with other F-box proteins may obscure its specific contributions .

Inferred Roles from Related Proteins

1. Ethylene signaling: F-box proteins like EIN2-TARGETING PROTEIN1 (ETP1) regulate ethylene receptor stability . At3g19410 may modulate similar pathways.

2. Protein quality control: Kelch repeats often bind misfolded proteins or specific motifs (e.g., phosphorylated residues) .

Future Directions

• Structural analysis: Cryo-EM studies to resolve At3g19410’s interaction with SCF complex components .

• Phenotypic profiling: at3g19410 knockout plants under biotic/abiotic stress to identify functional deficits .