FCAR Antibody

• FcalphaRI-induced cytokine production is mediated by upregulation of cytokine translation and caspase-1 activation, processes dependent on glycolytic reprogramming. PMID: 29491406
• In transgenic mice, IgA nephropathy (IgAN) pathogenesis involves impaired clearance of abnormal IgA via CD89, primarily by Kupffer cells. Conditional IgAN progression in CD89 transgenic mice highlights key aspects of IgAN pathogenesis. PMID: 27437939
• A novel Fcar splice variant (variant APD), lacking the IgA-binding EC1 domain, has been identified in a healthy volunteer. PMID: 28103138
• Findings suggest the Fc receptor I for IgA (FcalphaRI) is a potential molecular target for lupus treatment. PMID: 25907714
• FcalphaRI induces various forms of neutrophil death depending on the inflammatory microenvironment. PMID: 25339672
• A study examined the expression of IL-4 mRNA, IFN-γ mRNA, and FcaRI mRNA in tonsillar mononuclear cells from IgA nephropathy (IgAN) and non-IgAN patients. PMID: 24732061
• FCAR polymorphism is not significantly associated with increased susceptibility to IgA nephropathy in Caucasian populations. PMID: 21750160
• Abnormally glycosylated IgA1 and soluble CD89-IgA and IgA-IgG complexes, characteristic of primary IgA nephropathy, are also present in alcoholic cirrhosis. PMID: 21866091
• Genetic variation in the IgA receptor promoter region is associated with IgA nephropathy. PMID: 21273231
• Results suggest a role for anti-FcaRI Fab as a negative regulator in controlling the magnitude of the innate immune response. PMID: 21985370
• Glycosylation of the CH2/CH3 interface inhibits interaction with the pathogen IgA binding protein SSL7, while maintaining binding of pIgR, crucial for SIgA biosynthesis and transport. PMID: 21784854
• Human mammary carcinoma cells are efficiently killed when incubated with human neutrophils and tumor-specific FcalphaRI bispecific antibodies or IgA antibodies. PMID: 21653835
• The Fc(α)RI 844 A>G polymorphism is not associated with systemic sclerosis or rheumatoid arthritis susceptibility. PMID: 21159834
• FcalphaRI defines a function for pentraxins in inflammatory responses involving neutrophils and macrophages, highlighting the innate aspect of humoral immunity-associated antibody receptors. PMID: 21383176
• Serum levels of sCD89-IgA complexes correlate with IgA nephropathy severity, suggesting a possible genetic component in regulating sCD89 production or expression. PMID: 20811333
• FcalphaR endocytosis is clathrin- and dynamin-dependent, but not regulated by Rab5; the endocytic motif is not located in the cytoplasmic domain of FcalphaR. PMID: 19859085
• CD89 circulates in a high molecular mass form, covalently linked to IgA, contributing to polymeric serum IgA formation. PMID: 11801662
• Expression of the FcR splice isoform ΔEC2, but not Δ66EC2, is differentially regulated in a cell type-specific manner and in response to inflammatory and/or infectious processes. PMID: 12560105
• The Fc alpha receptor 5'-flanking region (-102 to -64 relative to the ATG translation initiation codon) is essential for promoter activity and contains two functional binding motifs for C/EBP and Ets family members. PMID: 12594283
• A bivalent, pH-dependent interaction exists between FcalphaRI and IgA, impacting cytokine-dependent IgA phagocytosis and FcalphaRI-mediated IgA degradation or recycling. PMID: 12634059
• Crystal structures of human FcalphaRI alone and complexed with the Fc region of IgA1 (Fcalpha) have been determined. PMID: 12768205
• Crystal structure of the human FcalphaRI ectodomain has been solved. PMID: 12783876
• The expression pattern of CD89 and its signaling subunit, the FcR γ chain, has been characterized on circulating myeloid cells and in various tissues. PMID: 12791088
• FcalphaRI expressed by interstitial-type dendritic cells may play a crucial role in sampling IgA-recognized antigens and during dendritic cell activation. PMID: 15371488
• Group A and B streptococci produce virulence factors that block IgA binding to FcαRI, inhibiting IgA-mediated immunity. PMID: 16293625
• Fc receptor gamma RI interacts with the immunoreceptors FcalphaRI and FcepsilonRI (FCalphaRI, also known as CD89). PMID: 16627486
• GPVI utilizes different structural domains to interact with various agonists; different sites on GPVI represent potential targets for antagonist development. PMID: 16876821
• On monomeric targeting, FcalphaRI functions as an FcRγ ITAM-dependent apoptotic module, potentially crucial for controlling inflammation and tumor growth. PMID: 16990604
• Carriers of the 92Asn polymorphism in the myeloid IgA Fc receptor showed increased risk of myocardial infarction (CARE study) and increased odds of coronary heart disease (WOSCOPS study). PMID: 17008591
• FCAR promoter SNPs may be linked to chronic HCV infection and disease progression in Japanese patients with chronic hepatitis C. PMID: 17033823
• Fc alpha receptor type I activation mediates glomerulonephritis progression by initiating a cytokine/chemokine cascade that promotes leukocyte recruitment and kidney damage in transgenic mice. PMID: 17393381
• Results suggest an endogenous mechanism down-regulating FcalphaR functionality in allergic environments where FcepsilonRI is co-expressed and extensively cross-linked on FcalphaR-expressing effector cells. PMID: 18700185
• IgA:Fc(α)RI interactions induce neutrophil migration via leukotriene B4 release. PMID: 19555692
• Pathogen selection by bacterial decoy proteins drives FcalphaRI and IgA-Fc co-evolution. PMID: 17548632

HGNC: 3608

OMIM: 147045

KEGG: hsa:2204

STRING: 9606.ENSP00000347714

UniGene: Hs.659872