FCGR2A Antibody, HRP conjugated

1. CD32 expression serves as a marker of CD4+ T cell activation in individuals living with HIV. PMID: 30013105
2. This research indicates that genetic variation in human neutrophil Fcgamma receptors and SIRPalpha influences antibody-dependent cellular cytotoxicity towards cancer cells. PMID: 28952147
3. This study highlights the impact of FCGR genetic polymorphism on antibody responses to GARP in patients with breast cancer. PMID: 29879453
4. Data suggests that FC gamma receptor FCGR2A polymorphisms do not significantly influence the response to rituximab in patients with immune thrombocytopenic purpura (ITP). PMID: 28856973
5. Results revealed a significantly higher frequency of FC gamma receptor FCGR3A-158V allele in patients with immune thrombocytopenia (ITP) compared to control subjects. However, no significant differences were found in the genotype distribution or allele frequencies for FC gamma receptor FCGR2A-131H/R between patients and controls. PMID: 28942727
6. Differently oxidized isolated subspecies can lead to both stronger and weaker binding and activation of the histidine variant of Fc fragment of IgG receptor IIa (FcgammaRIIa). PMID: 28988621
7. CRP binds to surface CD32 (also known as FcgammaRII) on myeloma cells, activating a pathway mediated by the kinase p38 MAPK and the transcription factor Twist, which enhances the cells' secretion of osteolytic cytokines. PMID: 29233917
8. FCGR2A single nucleotide polymorphism is linked to susceptibility to idiopathic nephrotic syndrome. PMID: 29155175
9. The alphaIIb beta3 antagonist TMV-7/trimucrin prevents thrombosis without causing Fc receptor gamma-chain IIa-mediated thrombocytopenia. PMID: 28815933
10. The expression levels of human FcgammaRIIB, but not FcgammaRIIA, were negatively correlated with serum levels of IgE in human asthma patients. PMID: 29597194
11. When higher-affinity genotypes for FCGR2A, FCGR3A, and FCGR2C were considered together, they were associated with significantly increased tumor shrinkage and prolonged survival in response to HD-IL2. This is the first study to demonstrate associations between FCGR genotypes and outcome following HD-IL2 treatment. PMID: 27742794
12. FcgammaRIIA and FcgammaRIIB both showed increased methylation levels in Kawasaki disease (KD) patients who underwent IVIG treatment. FcgammaRIIA expression influenced the IVIG treatment response in KD patients. The FcgammaRIIA/IIB mRNA expression ratio was higher in KD patients with coronary artery lesion formation. PMID: 27893416
13. FCGR2A rs1801274 G-allele is associated with susceptibility to Kawasaki disease and Ulcerative colitis. PMID: 27270653
14. Farletuzumab demonstrates enhanced binding to FCGR3A-158V high-affinity receptor and an enhanced clinical outcome in ovarian cancer patients with low baseline CA125 levels and at least one high-affinity allele of FCGR2A or FCGR3A. PMID: 29041009
15. Inhibition of Abl/Src with bosutinib reduced FcgammaRIIA-mediated glomerular neutrophil accumulation and renal injury in experimental, crescentic anti-GBM nephritis. PMID: 28891817
16. This study demonstrates that p.His167Arg, a KD-associated FCGR2A variant, acts as a susceptibility gene in males only. The gender differences associated with FCGR2A in KD provide new insights into KD susceptibility. PMID: 28886140
17. Data suggests a mechanism where Toll-like receptors TLR7/8 signaling, through shedding of FcgRIIA, shifts neutrophil function from phagocytosis to a programmed necrosis pathway, neutrophil extracellular trap formation (NETosis). PMID: 28606989
18. Gene copy number variation (CNV) of the PKLR, FCGR2A, FCGR2C, and FCGR3 genes is associated with malaria severity. These findings provide evidence for a role of CNV in host responses to malaria. PMID: 28605553
19. This research indicated no association between FCGR2A polymorphisms in Guillain-Barre Syndrome in a Brazilian population. PMID: 27609290
20. FCGR3A V and FCGR2A R allele carriers exhibit better responsiveness to anti-TNF-alpha therapy. This is a review article. PMID: 27490376
21. Association between Fc gamma receptor IIA genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya. PMID: 28427365
22. This study identified a subpopulation of 0.012% of CD4 T cells that express CD32a and host up to three copies of HIV DNA per cell. This CD32a(+) reservoir was highly enriched in inducible replication-competent proviruses and can be predominant in some participants. The potential identification of CD32a(+) lymphocytes as the elusive HIV-1 reservoir could lead to insights that facilitate specific targeting and elimination of this reservoir. PMID: 28297712
23. Single nucleotide polymorphisms (SNPs) rs2099684 in IgG receptors FCGR2A/FCGR3A can be considered a genetic risk factor for Takayasu arteritis (TA) in the Chinese Han population. PMID: 27769046
24. The mutant homozygote (CC) of the FCGR2A gene (rs1801274) may have a protective role among Chinese patients with UC. PMID: 27984611
25. This is a review/meta-analysis suggesting that FcgammaRIIa-H131R may modify treatment response to rituximab in diffuse large B cell lymphoma. PMID: 28039707
26. FCGR2A and FCGR2C polymorphisms may also contribute to immunocomplexemia present in sarcoidosis. PMID: 26801149
27. The absence of TULA-2 and the relative level of TULA-2 expression modulate FcgammaRIIA-mediated platelet reactivity and heparin-induced thrombocytopenia in vivo. PMID: 27765766
28. FCGR2A expression is significantly upregulated in human masticatory mucosa during wound healing. PMID: 28005267
29. This is a review/meta-analysis suggesting that rheumatoid arthritis patients with FCGR2A HH + HR genotype show a poor response to adalimumab. PMID: 27074847
30. Our findings indicate that CD16 158F>V polymorphism may contribute to the increased risk of Idiopathic Thrombocytopenic Purpura, whereas CD32 131H>R polymorphism may not be a significant risk factor for Idiopathic Thrombocytopenic Purpura. PMID: 27315784
31. Our observations support the existence of a central FcgammaRIIA-mediated pathway through which human platelets respond to both Gram-negative and Gram-positive bacteria. PMID: 27025455
32. FcgammaRIIA H131 allele and FcgammaRIIA H/H131 genotype were significantly increased in pediatric Guillain-Barre syndrome patients. PMID: 27064330
33. FCGR2A/FCGR3A-related immune disorder might contribute to the etiology of Takayasu arteritis. PMID: 26996483
34. Data indicates no significant difference in the allele or genotype frequencies of the Fcgamma2RA protein (FCGR2A) rs1801274 single nucleotide polymorphism observed between groups. PMID: 27267995
35. The RR, HR, and HH FCGR2A-131 genotypes were detected in 1 (11%), 5 (56%), and 3 (33%) of patients with disease relapse compared to 25 (21%), 56 (47%), and 38 (32%) of the 119 patients without relapse. PMID: 27376362
36. The data suggests that FcgammaRIIA genotyping can be used as a marker of genetic susceptibility to sepsis. PMID: 26490967
37. FCGR3A and FCGR2A SNPs do not confer differential responsiveness to rituximab. PMID: 26510856
38. Fc-gamma receptor polymorphisms differentially influence susceptibility to systemic lupus erythematosus and lupus nephritis. PMID: 26748351
39. R/R genotype of FCGR2A p.R131H and G/G genotype of CCL2 c.-2518 A > G polymorphisms are associated with thrombocytopenia, which is a characteristic laboratory finding in dengue infections. PMID: 26429304
40. Genetic variants of rs6671847 at FCGR2A and rs17085007 at 13q12 conferred a risk of relapse in patients with ulcerative colitis. PMID: 25787843
41. This research did not find a significant association between FCGR2A H131R and clinical outcome in KRAS wild metastatic colorectal cancer individuals with adjuvant cetuximab therapy. PMID: 26363448
42. The results demonstrate an association between FcgRIIa, TNF-alpha, and IL-6 gene single nucleotide polymorphisms and symptom persistence in Dengue patients. PMID: 26429310
43. FCGR2A polymorphisms constitute a risk factor for graft loss following kidney transplantation, and this effect is related to anti-HLA antibodies. PMID: 26429312
44. FcgammaRIIIA/FcgammaRIIA gene polymorphisms and HER-2 may play a role in antibody-dependent cellular cytotoxicity and clinical response to trastuzumab in breast cancer. PMID: 26450443
45. The study aimed to develop a novel method for Y402H (g.43097C>T) genotyping, confirm its association with AMD in the Greek population, and investigate the H131R polymorphism in AMD. PMID: 25811666
46. These include an FCGR2A/2C chimeric gene that causes decreased expression. PMID: 26133275
47. Genetic variation in Fc gamma receptor IIA may contribute to infectious susceptibility in trauma patients. PMID: 26496101
48. This meta-analysis suggests that the H131R polymorphism in the FCGR2A gene might be associated with susceptibility to KD in Asians. PMID: 26125827
49. The study found that homozygous carriers of the FcgammaRIIA-131R/R allele had higher malaria-specific antibody levels compared to heterozygous carriers of FcgammaRIIA-131R/H alleles and homozygous carriers of FcgammaRIIA-131H/H alleles. The pre-existing antibody responses were related to reduced subsequent risk of clinical malaria. PMID: 25447268
50. This is a review discussing the role of human FCGR2A in immune processes and thrombosis. PMID: 25900780

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HGNC: 3616

OMIM: 146790

KEGG: hsa:2212

STRING: 9606.ENSP00000271450

UniGene: Hs.352642