FGF18 Antibody

• FGF18 has been implicated in the growth and metastasis of breast cancer. PMID: 29901199
• A study in a Chinese population did not find a significant association between rs9313548 and developmental dyslexia, aligning with previous research. PMID: 29240020
• Research has demonstrated that miR-139 suppresses FGF18, consequently inhibiting proliferation, apoptosis, invasion, migration, and tumor-induced angiogenesis in hepatocellular carcinoma (HCC) cells. FGF18 is considered a potential prognostic biomarker and therapeutic target in HCC patients, and miR-139 could be a promising treatment strategy through FGF18 suppression. PMID: 28765917
• Findings suggest that FGF18 may be involved in MC3T3E1 cell proliferation and osteoblastic differentiation. PMID: 28765932
• FGF18 expression is significantly elevated in endometrioid adenocarinoma. PMID: 27267714
• FGF9 and FGF18 enhance the migratory capacity of human lung fibroblasts, and FGF9 actively modulates matrix metalloproteinase activity in idiopathic pulmonary fibrosis. PMID: 26773067
• FGF18 plays a critical role in the growth and migration of non-small cell lung cancer cells by regulating the ERK, p38 signaling pathways, and MMP26 protein levels. PMID: 27959447
• Data indicates that a combination of FIGO stage, ovarian carcinoma type, and/or fibroblast growth factor 18 (FGF18) score could predict poor prognosis among ovarian carcinoma patients. PMID: 26427667
• The position of sulfate ions bound to FGF18 provides insights into the putative HS-binding site and allows comparison with the prototypical FGFs, FGF1, and FGF2. PMID: 24668462
• FGF-18 plays a significant role in chondrogenic and osteogenic events that drive discal development and ossification of the vertebral bodies. PMID: 23397188
• Fgf18 has been identified as a molecule that protects articular cartilage. This protective effect may be partially mediated by the Timp1 expression. PMID: 24577103
• Tumors from ovarian cancer patients exhibit increased FGF18 expression levels, correlated with microvessel density and M2 macrophage infiltration. PMID: 24018557
• FGF8, FGF17, and FGF18 are involved in autocrine and paracrine signaling in HCC, enhancing the survival of tumor cells under stress conditions, malignant behavior, and neoangiogenesis. PMID: 21319186
• An association was observed between the gene FGF18 rs4043716 and nonsyndromic cleft lip with or without palate in the Chinese population. PMID: 19727229
• FGF2 and -18 bind to distinct structures on the heparan sulfate chains attached to chondrocyte-derived perlecan, modulating the growth factor activities. PMID: 20507176
• Fibroblast growth factor 18 appears to play a role in maintaining chondrocyte properties, although its expression was relatively high in dedifferentiated chondrocytes. PMID: 19909293
• Analysis of FGF18 and FGFR5 expression in primary endothelial cells and vascular smooth muscle cells. PMID: 16019430
• FGF18 is widely expressed in cardiovascular tissue. It enhances cell migration in response to mechanical damage. FGF18 expression was detected in liver vascular and liver sinusoidal endothelial cells (LSECs), but not in hepatic parenchymal cells. PMID: 16756958
• FGF18 may play a prominent role in chondrogenesis and osteogenesis during skeletal development and growth (review). PMID: 17128416
• FGF3, FGF7, FGF10, FGF18, and FGFR1 may have roles in nonsyndromic cleft lip and palate. PMID: 17360555
• FGF18 is generally overexpressed in colon cancer and exerts pro-tumorigenic effects in both the epithelial and stromal compartments by stimulating growth and survival of tumor cells, migration of fibroblasts, and neovascularization. PMID: 17890768

HGNC: 3674

OMIM: 603726

KEGG: hsa:8817

STRING: 9606.ENSP00000274625

UniGene: Hs.87191