FGF18 Antibody

1. FGF18 has been implicated in the growth and metastasis of breast cancer. PMID: 29901199
2. A study investigating the association between rs9313548 and developmental dyslexia in a Chinese population found no significant association. PMID: 29240020
3. Research has explored the suppressive effect of miR-139 on FGF18 and its impact on the proliferation, apoptosis, invasion, migration, and tumor-induced angiogenesis of hepatocellular carcinoma (HCC) cells. FGF18 has been proposed as a prognostic biomarker and therapeutic target in HCC patients, with miR-139 potentially serving as a promising therapeutic strategy by suppressing FGF18. PMID: 28765917
4. Studies suggest that FGF18 may be involved in the proliferation and osteoblastic differentiation of MC3T3E1 cells. PMID: 28765932
5. FGF18 expression is significantly elevated in endometrioid adenocarcinomas. PMID: 27267714
6. FGF9 and FGF18 have been shown to increase the migratory capacity of human lung fibroblasts, with FGF9 actively modulating matrix metalloproteinase activity in idiopathic pulmonary fibrosis. PMID: 26773067
7. FGF18 plays a critical role in the growth and migration of non-small cell lung cancer cells by regulating the ERK, p38 signaling pathways, and MMP26 protein levels. PMID: 27959447
8. Data suggest that combining FIGO stage, ovarian carcinoma type, and/or FGF18 score could predict poor prognosis in ovarian carcinoma patients. PMID: 26427667
9. The structural analysis of FGF18 provides insight into the putative heparin sulfate binding site and allows comparison with the prototypical FGFs, FGF1, and FGF2. PMID: 24668462
10. FGF-18 plays a role in chondrogenic and osteogenic events that drive discal development and ossification of the vertebral bodies. PMID: 23397188
11. Fgf18 has been identified as a molecule that protects articular cartilage, and its anticatabolic effects may be mediated at least partially by the Timp1 expression. PMID: 24577103
12. Tumors from ovarian cancer patients exhibit increased FGF18 expression levels, correlating with microvessel density and M2 macrophage infiltration. PMID: 24018557
13. FGF8, FGF17, and FGF18 are involved in autocrine and paracrine signaling in HCC, enhancing the survival of tumor cells under stress conditions, promoting malignant behavior, and stimulating neoangiogenesis. PMID: 21319186
14. A study in the Chinese population identified an association between gene FGF18 rs4043716 and nonsyndromic cleft lip with or without palate. PMID: 19727229
15. FGF2 and -18 bind to discrete structures on the heparan sulfate chains attached to chondrocyte-derived perlecan, modulating the growth factor activities. PMID: 20507176
16. Fibroblast growth factor 18 appears to play a role in maintaining chondrocyte properties, although its expression was relatively high in dedifferentiated chondrocytes. PMID: 19909293
17. Research has involved the analysis of FGF18 and FGFR5 expression in primary endothelial cells and vascular smooth muscle cells. PMID: 16019430
18. FGF18 is widely expressed in cardiovascular tissue. It enhances cell migration in response to mechanical damage. FGF18 expression has been detected in liver vascular and liver sinusoidal endothelial cells (LSECs), but not in hepatic parenchymal cells. PMID: 16756958
19. FGF18 may play a prominent role in chondrogenesis and osteogenesis during skeletal development and growth (review). PMID: 17128416
20. FGF3, FGF7, FGF10, FGF18, and FGFR1 may be involved in nonsyndromic cleft lip and palate. PMID: 17360555
21. FGF18 is often overexpressed in colon cancer and exerts pro-tumorigenic effects in both the epithelial and stromal compartments by stimulating tumor cell growth and survival, fibroblast migration, and neovascularization. PMID: 17890768

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HGNC: 3674

OMIM: 603726

KEGG: hsa:8817

STRING: 9606.ENSP00000274625

UniGene: Hs.87191