FH20 Antibody

Functional Role in Immune Regulation

FH20 is essential for FH’s ability to distinguish host cells from pathogens:

• Host Cell Protection: Binds to GAGs on host cells, positioning FH19 to inactivate surface-bound C3b via cofactor activity .

• Pathogen Clearance: Fails to bind pathogen surfaces lacking GAGs, allowing complement activation .

• Disease Link: Mutations in FH20 disrupt C3b binding, leading to uncontrolled complement activation and aHUS .

Association With aHUS

• Mutation Hotspot: Over 50% of aHUS-linked FH mutations occur in SCR20, impairing C3b binding .

• Functional Defects: Mutants like R1210C reduce C3b binding affinity by >90%, increasing complement-mediated endothelial damage .

Comparative Analysis of FH20 Antibody Studies

Table 2: Key Studies on FH20 Antibody Interactions

Future Directions

• Mechanistic Studies: Resolving how FH20 balances dual binding to C3b and GAGs could inform therapeutic design.

• Antibody Engineering: Developing bispecific antibodies that enhance FH20’s protective role without triggering autoimmunity.