FKBP17-1 Antibody

Overview of FKBP Proteins

FK506-binding proteins (FKBPs) are immunophilins involved in protein folding, cellular signaling, and immune regulation. While "FKBP17-1" isn’t explicitly described in current databases, closely related family members include:

Potential Characteristics of FKBP17 Antibodies

While FKBP17-specific antibodies are not directly documented, insights can be extrapolated from structurally similar FKBP antibodies:

Key Features of FKBP Antibodies

• Target Specificity: Most FKBP antibodies (e.g., FKBP11, FKBP51) recognize conserved epitopes within the FK506-binding domain .

• Applications:

  • Western blot (WB): Common for detecting endogenous proteins (e.g., FKBP11 at 24 kDa ).

  • Immunohistochemistry (IHC): Used in cancer research (e.g., FKBP1A in hepatocellular carcinoma ).

  • Functional assays: Blocking FKBP-ligand interactions (e.g., FK506-mediated immunosuppression ).

FKBP11 Antibody (Proteintech 17467-1-AP)

FKBP51 Antibody (ab126715)

Functional Implications in Disease

• Cancer: FKBP1A correlates with PD-L1 expression and M2 macrophage infiltration in liver cancer, suggesting immune evasion roles .

• Fibrosis: FKBP11 is overexpressed in lung fibrosis plasma cells, acting as an antibody peptidyl-prolyl isomerase .

• Angiogenesis: FKBPL-derived peptides inhibit endothelial cell migration and tumor growth via CD44 .

Unresolved Questions

• FKBP17-1 Specificity: Whether FKBP17-1 refers to a splice variant, post-translationally modified form, or novel isoform remains unclear.

• Therapeutic Potential: FKBP ligands (e.g., FK506, rapamycin) show immunosuppressive effects, but FKBP17-targeted agents are unexplored .