FLA18 Antibody
Description
Claudin-Antibodies
Claudin-18 isoform 2 (CLDN18.2) antibodies are engineered to target gastric and pancreatic adenocarcinoma biomarkers. These antibodies are often labeled with fluorophores like fluorescein isothiocyanate (FITC) or phycoerythrin (PE) for diagnostic applications:
Key Research Findings:
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Claudin-18.2 is overexpressed in 60–70% of gastric cancers, making it a therapeutic target .
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Fluorophore labeling via FluoSite™ preserves antigen-binding functionality by conjugating fluorophores distal to the binding domain .
Fluorine-18-Labeled Antibodies
Fluorine-18 (¹⁸F) is used in positron emission tomography (PET) to label antibodies for imaging amyloid-β (Aβ) plaques in Alzheimer’s disease:
Key Research Findings:
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¹⁸F-labeled bispecific antibodies show high BBB penetration and Aβ-specific binding in transgenic mouse models .
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Defluorination issues were resolved using optimized tetrazine variants (e.g., [¹⁸F]T3) .
Anti-CD18 Antibodies
CD18 (integrin β2) antibodies, such as M18/2, block leukocyte adhesion in inflammatory responses:
| Property | M18/2 Anti-CD18 Antibody |
|---|---|
| Target | CD18 (LFA-1 β-subunit) |
| Applications | Flow cytometry, functional blockade |
| Neutralization | 45–55% HIV neutralization synergy with plasma |
| Purity | >90% (SDS-PAGE) |
Key Research Findings:
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Anti-CD18 antibodies enhance plasma-mediated HIV neutralization by up to 80% .
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Used at ≤0.5 µg/test in flow cytometry with mouse splenocytes .
Methodological Advances in Antibody Labeling
Fluorophore and isotope labeling techniques are critical for diagnostic/therapeutic applications:
Product Specs
Constituents: 50% Glycerol, 0.01M Phosphate Buffered Saline (PBS), pH 7.4
