FPR3 Antibody
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In Stock 
Product Specs
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Lead Time
Typically, we can ship your order within 1-3 business days of receiving it. Delivery times may vary depending on your location and shipping method. Please contact your local distributor for specific delivery times.
Synonyms
FPR3; FPRH1; FPRL2; N-formyl peptide receptor 3; FMLP-related receptor II; FMLP-R-II; Formyl peptide receptor-like 2
Target Names
Uniprot No.
Target Background
Function
FPR3 is a low affinity receptor for N-formyl-methionyl peptides, which are potent neutrophil chemotactic factors. Binding of FMLP to the receptor triggers neutrophil activation. This response is mediated through a G-protein that activates a phosphatidylinositol-calcium second messenger system. FPR3 also functions as a receptor for humanin.
Gene References Into Functions
- The successful production of properly folded and functional human FPR3 using cell-free methods provides a new avenue for the rapid and efficient generation of human FPRs (and even other GPCRs) for structural and functional analyses. PMID: 23746112
- Transcriptional variations of FPR3 arise through an alternative promoter during primate evolution. PMID: 21717223
- F2L peptide, derived from the processing of nanomolar concentrations of heme-binding protein (HEBP)1, is active on FPR3 and capable of inducing recruitment of FPR3-expressing monocytes, macrophages, and mouse neutrophils. PMID: 21709160
- Research indicates that uPAR expression regulates the adhesive and migratory ability of CXCR4-expressing cells through a mechanism involving fMLP receptors and alpha-v integrins. PMID: 20972812
- Human dendritic cells express functional FPRL2 throughout maturation. FPRL2 and its endogenous ligand may play a role in regulating DC trafficking during antigen uptake and processing, as well as the T-cell-stimulating phase of immune responses. PMID: 12223529
- Activation of FPRL2 inhibits lipopolysaccharide-induced dendritic cell maturation. PMID: 16002663
- However, F2L inhibits formyl peptide receptor (FPR) and FPRL1 activities, resulting in the inhibition of intracellular calcium increases and superoxide generation induced by N-formyl-Met-Leu-Phe, MMK-1, or Trp-Lys-Tyr-Met-Val-d-Met in neutrophils. PMID: 17577578
- FPRL2 is expressed and functional in macrophages differentiated from monocytes in vitro under various conditions. PMID: 19342677
- Human monocytes express FPR1, FPR2, and FPR3; human neutrophils express FPR1 and FPR2, but not FPR3. PMID: 19843937
Database Links
Protein Families
G-protein coupled receptor 1 family
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Tissue Specificity
Detected in various tissues with highest expression in lung.
Customer Reviews
,
B.A
By Anonymous
★★★★★
Applications : Immunohistochemistry (IHC)
Sample type: human Breast Cancer Tissue
Sample dilution: 1：150
Review: I used CSB-PA008856LA01HU antibody in the immunohistochemical detection of breast cancer patients, and the dilution of 1:150 can achieve good results. Recommended for use.
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