FRO6 Antibody

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Description

Analysis of Available Data

The absence of "FRO6 Antibody" in peer-reviewed literature, antibody databases (IEDB, AbNGS), or therapeutic registries (Antibody Society) suggests it may:

  • Be a proprietary or experimental agent not yet published.

  • Refer to a misidentified or non-standardized nomenclature.

  • Relate to a niche application or preclinical study outside the scope of the provided sources.

Key Observations

Search ComponentOutcome
Therapeutic Antibody ListsNo entries matching "FRO6" in approved or investigational antibody databases .
Antibody Sequence DatabasesNo CDR3 or VH sequences linked to "FRO6" in AbNGS, IEDB, or other repositories .
Disease-Specific StudiesNo association with HPV, SARS-CoV-2, or other pathogens in indexed research .
Structural/Functional DataNo CDR, Fc modifications, or binding affinity metrics matching "FRO6" .

Recommendations for Further Inquiry

To address this knowledge gap, consider:

  1. Nomenclature Clarification: Verify alternative names or abbreviations (e.g., "FRO6" may refer to a target antigen, epitope, or internal project code).

  2. Target-Specific Databases: Explore specialized repositories like:

    • ClinicalTrials.gov for unindexed trials.

    • PatentScope (WIPO) for proprietary antibody disclosures.

  3. Direct Outreach: Contact antibody manufacturers or research institutions for unpublished data.

Hypothetical Framework for "FRO6 Antibody" Analysis

If "FRO6 Antibody" were a theoretical or emerging agent, its characterization would follow established protocols :

PropertyHypothetical Specification
TargetUnidentified (requires validation via KO cell lines or orthogonal methods)
IsotypeUnknown (common therapeutic isotypes: IgG1, IgG4, IgA)
Effector FunctionFc modifications (e.g., FcγRIIIa binding, ADCC enhancement) would depend on Fc engineering .
Binding AffinityMeasured via SPR or AlphaSeq assays (typical therapeutic range: 1 pM – 100 nM) .
Clinical ApplicationSpeculative (e.g., oncology, infectious diseases, autoimmune disorders).

Product Specs

Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
FRO6 antibody; At5g49730 antibody; K2I5.9 antibody; Ferric reduction oxidase 6 antibody; AtFRO6 antibody; EC 1.16.1.7 antibody; Ferric-chelate reductase 6 antibody
Target Names
FRO6
Uniprot No.

Target Background

Function
FRO6 is a ferric chelate reductase involved in iron uptake by shoot and leaf cells. It may participate in the transport of electrons to a Fe(3+) ion via FAD and heme intermediates.
Gene References Into Functions
  1. FRO6 functions as a ferric chelate reductase, facilitating iron uptake by leaf cells. PMID: 21104018
  2. FRO6 expression is regulated by light and responds to developmental cues, enabling the acquisition of iron in a tissue- or cell differentiation-specific manner. PMID: 16489134
Database Links

KEGG: ath:AT5G49730

STRING: 3702.AT5G49730.1

UniGene: At.29770

Protein Families
Ferric reductase (FRE) family
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Tissue Specificity
Expressed in shoots and leaves. Detected in cotyledons, stems, siliques, flowers, sepals, anther filaments and stigmas, but not in roots.

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