FUM2 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% ProClin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
14-16 weeks (made-to-order)
Synonyms
FUM2 antibody; At5g50950 antibody; K3K7.11Fumarate hydratase 2 antibody; AtFUM2 antibody; Fumarase 2 antibody; EC 4.2.1.2 antibody
Target Names
FUM2
Uniprot No.
Target Background
Function
This antibody targets cytosolic fumarate hydratase, an enzyme catalyzing the reversible, stereospecific interconversion of fumarate and L-malate. Specifically, it catalyzes the dehydration of L-malate to fumarate in the cytosol. This is crucial for the significant fumarate accumulation observed in plants grown under high nitrogen conditions during daylight hours. Furthermore, this enzyme is essential for photosynthetic acclimation to cold temperatures, mediating fumarate accumulation under low temperatures and subsequently reducing the accumulation of phosphorylated sugars.
Gene References Into Functions
The role of FUM2 is supported by the following research:
1. Studies of FUM2-deficient mutants reveal significant alterations in their cold response, affecting both metabolite concentrations and gene expression. [PMID: 27440755]
2. FUM2 is necessary for leaf fumarate accumulation, a process critical for rapid nitrogen assimilation and growth under high-nitrogen conditions. [PMID: 20202172]
Database Links
Protein Families
Class-II fumarase/aspartase family, Fumarase subfamily
Subcellular Location
Cytoplasm, cytosol.
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