FYPP3 Antibody

FYPP3 is the catalytic subunit of protein phosphatase 6 (PP6), which is involved in a variety of cellular processes, including:

• Photoperiodic control of flowering time: FYPP3 dephosphorylates phosphorylated phytochromes, particularly the Pfr forms, playing a key role in modulating phytochrome signals in long-day flowering plants.
• Regulation of polar auxin transport: FYPP3 directly dephosphorylates the auxin efflux carriers PIN1 and PIN2, promoting their proper localization in the root cell plasma membrane. This regulation, in conjunction with the protein kinase PID, ensures proper polar auxin transport and plant development.
• Abscisic acid (ABA) signaling during seed germination and seedling growth: FYPP3 acts as a negative regulator of ABA signaling by dephosphorylating and destabilizing the ABI5 protein. This action is antagonistic to the protein kinase SRK2E/SNRK2.6, influencing ABA responses.
• Hypocotyl phototropism: FYPP3 contributes to the regulation of phosphorylation status in hypocotyl phototropism.
• Negative regulation of photomorphogenesis: In the dark, FYPP3 controls the stability and transcriptional activity of PIF3 and PIF4 proteins by regulating their phosphorylation status, ultimately influencing photomorphogenesis.

Further research has revealed the following specific functions of FYPP3:

1. FYPP3, alongside FyPP1, directly dephosphorylates ABI5 and regulates abscisic acid signaling. PMID: 23404889
2. FYPP3 forms a PP6-type phosphatase holoenzyme, directly regulating auxin efflux. PMID: 22715043

KEGG: ath:AT3G19980

STRING: 3702.AT3G19980.1

UniGene: At.5940