GABBR2 Antibody

• GABA B receptor expression in myometrium PMID: 30343129
• Research suggests that the GABBR2 gene may be a novel potential epigenetic treatment target when combined with erlotinib treatment for stage IIIa (N2) EGFR 19 deletion lung adenocarcinoma. PMID: 28490462
• While no statistically significant association was found for the two SNPs of the GABBR1 gene (rs29230 and rs29267), a significant difference was observed at the genotype level for rs2900512 of the GABBR2 gene between individuals with alcohol use disorder (AUD) and controls. PMID: 28118741
• Missense mutations in the GABBR2 gene have been linked to neurodevelopmental disorders. PMID: 28867141
• GABBR2 is a genetic factor that influences the expression of Rett syndrome or epileptic encephalopathy-like phenotypes, depending on the variant positions. GABBR2-mediated gamma-aminobutyric acid signaling is a crucial factor in determining the severity and nature of neurodevelopmental phenotypes. PMID: 28856709
• Using a ligand-guided approach, eight GABAB2 homology models have been identified as potential structural representatives of the transmembrane domain of the GABAB2 subunit. PMID: 28323850
• A GABBR2 variant, predicted to be disease-causative, showed a significant association with corticospinal excitability after correction for multiple comparisons. Further exploratory analysis revealed associations between GABBR2, GABRA2, and DRD2 variants with transcranial magnetic stimulation measures of corticospinal excitability and cortical inhibition in Huntington's disease, as well as with age at onset. PMID: 27033668
• Rare variants in GABBR2 were found to be significantly associated with smoking status. PMID: 25450229
• GABBR2 receptors are expressed in aortic smooth muscle cells and regulate intracellular calcium ion concentration ([Ca(2+)]i) through a Gi/o-coupled receptor pathway and a phospholipase C activation pathway. PMID: 24682435
• Putative GABAA and ASIC1a channels functionally interact, possibly via an inter-molecular association to form a novel protein complex. PMID: 24923912
• The endoplasmic reticulum retention signal of GBR1 is not part of the core coiled-coil structure, suggesting that it is sterically shielded by GBR2 upon heterodimer formation. PMID: 24778228
• Proteasomal degradation of gamma-aminobutyric acidB receptors is mediated by the interaction of the GABAB2 C terminus with the proteasomal ATPase Rtp6 and is regulated by neuronal activity. PMID: 24482233
• While GABABR1 and GABABR2 proteins are reduced in the prefrontal cortex of aged rats, these reductions are not associated with spatial learning abilities. PMID: 22169202
• Findings indicate that both R1 and R2 subunits of GABA(B) receptors must be activated for the modulation of N-type (Ca(v)2.2) calcium channels by analgesic alpha-conotoxins Vc1.1 and RgIA. PMID: 22613715
• The GABBR2 ectodomain adopts a constitutively open conformation, suggesting a structural asymmetry in the active state of GABA(B) receptors that is unique to the GABAergic system. PMID: 22660477
• Research suggests that specific GABA receptor gene expression variations, particularly involving the GABRA3 and GABBR2 genes, may be associated with migraine. PMID: 21971078
• Internalization of gamma-aminobutyric acid type B (GABA(B)) receptors is regulated by the R2 subunit. PMID: 21724853
• A study has provided evidence of Gabbr2 deficiency in schizophrenia and mood disorders. PMID: 21303731
• Levels of GABA(B) receptor subunit 2 are significantly decreased in the cingulate cortex and fusiform gyrus of autism patients compared to controls. PMID: 20557420
• Variants of GABBR1 and GABBR2 are associated with nicotine dependence in European- and African-American populations. PMID: 19763258
• Increased expression of GABA(B) receptor subtype 2 indicates augmented presynaptic inhibition of glutamate release, which may serve as a protective mechanism in temporal lobe epilepsy. PMID: 14625043
• The GABA(B)R2 receptor subunit is found on the same neurons and exhibits similar distribution patterns in the basal ganglia as the GABABR1 receptor subunit. PMID: 14961561
• Association of the GABA(B)R1 with the GABA(A) receptor gamma2S subunit significantly promotes cell surface expression of GABA(B)R1 in the absence of GABA(B)R2, which is typically required for efficient trafficking of GABA(B)R1 to the cell surface. PMID: 14966130
• Functional GABA(B) receptors, composed of heterodimers with GABA(B1) and GABA(B2) subunits, are present in the human colon. PMID: 14978362
• Functional GABA(B) receptors are expressed in human airway smooth muscle cells. PMID: 16829628
• GABA(B) receptor stability and signaling can be modulated through interactions between the GABA(B) receptor subunit 2 and the PDZ scaffold protein Mupp1, which may contribute to cell-specific regulation of GABA(B) receptors in the central nervous system. PMID: 17145756
• Levels of GABBR1 are significantly decreased in the cerebellum of patients with autism. PMID: 19002745

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HGNC: 4507

OMIM: 607340

KEGG: hsa:9568

STRING: 9606.ENSP00000259455

UniGene: Hs.198612