GADD45G Antibody

1. A study on an Eastern Chinese population found that individuals carrying the GADD45G rs8252T variant genotype had a significantly lower risk of developing non-small-cell lung cancer (NSCLC). Individuals with the CT/TT genotypes of the rs8252 variant displayed significantly higher levels of GADD45G mRNA expression compared to those with the CC genotype in the target tissues. There was some evidence of interactions between the rs8252 genotypes and sex regarding NSCLC risk. PMID: 27861856
2. In contrast to solid tumors, the frequency of GADD45gamma methylation is higher in diffuse large B-cell lymphoma (DLBCL) and may be associated with disease progression. Nodal involvement is more likely to be present in patients with unmethylated GADD45gamma. PMID: 25912017
3. PAX5 has been identified as an epigenetically inactivated tumor suppressor that inhibits non-small-cell lung proliferation and metastasis by down-regulating the beta-catenin pathway and up-regulating GADD45G expression. PMID: 26843424
4. GADD45G protein, human PMID: 26521045
5. Research indicates that the downregulation of the GADD45G-SIP1 axis may contribute to cellular senescence evasion and the development of hepatocellular carcinoma (HCC). PMID: 26378039
6. Studies have shown that GADD45gamma expression in hepatocellular carcinoma cells is associated with sensitivity to sorafenib. PMID: 26172295
7. Research has demonstrated for the first time that miR-383 specifically regulates the expression of Gadd45g by directly targeting the 3'-UTR region of Gadd45g mRNA. This regulatory process is conserved in human tumor cells and mouse embryonic stem cells. PMID: 25415264
8. Expression of GADD45gamma was found to be significantly higher in pituitary adenomas of female patients. PMID: 25126861
9. Research suggests that cucurbitacin E-induced mitosis delay is regulated by GADD45gamma overexpression in malignant gliomas. PMID: 24577085
10. GADD45G functions as a negative regulator of the Jak-Stat3 pathway and inhibits hepatocellular carcinoma by inducing cellular senescence. PMID: 23897841
11. The gadd45g gene exhibits both tumor suppressor and tumor promoter functions, depending on the tissue/cell type and transforming event. (Review) PMID: 24104471
12. Decreased expression and aberrant methylation of Gadd45G are associated with tumor progression in esophageal squamous cell carcinoma. PMID: 23793925
13. Methylation-mediated repression of GADD45G expression is associated with gastric cardia adenocarcinoma. PMID: 23616123
14. Additionally, eight genes classified as 'second tier' hits in an original study (PAX7, THADA, COL8A1/FILIP1L, DCAF4L2, GADD45G, NTN1, RBFOX3, and FOXE1) showed evidence of linkage and association in a replication sample. PMID: 23512105
15. Knockdown of GADD45gamma significantly attenuates TNF-α and IL-6 production in the human monocyte-macrophage THP-1 cell line as well as in human peripheral blood mononuclear cells. PMID: 22752116
16. Clinically non-functioning adenomas exhibited a significant decrease (P<0.001) in the relative levels of GADD45c expression (13 of 14 adenomas or 92%), compared to functioning adenomas (11 of 24 or 46%). PMID: 21850407
17. Data show that mda-7/IL-24 activation leads to upregulation of growth arrest and DNA damage-inducible (GADD) 45 alpha and gamma and JNK activation. PMID: 21931671
18. These results reveal the mechanism of self-association by Gadd45 proteins and the importance of this self-association for their biological function. PMID: 22058036
19. The induction of GADD45gamma gene expression by 1,25-(OH)2D3 may mark therapeutic response in prostate cancer. PMID: 20739400
20. Epigenetic regulation of GADD45G is associated with carcinogenesis in stomach, colorectal, and pancreatic cancers. PMID: 20111973
21. Flow cytometric analysis revealed significant G2/M arrest in cells transfected with either Gadd45alpha or Gadd45gamma. Importantly, we found that expression of either Gadd45alpha or Gadd45gamma activated P38 and JNK kinase pathways to induce G2/M arrest. PMID: 19048389
22. GADD45G is a potent growth suppressor that controls pituitary cell proliferation and is the first identified gene whose expression is lost in the majority of human pituitary tumors. PMID: 11889197
23. Research suggests that CRIF1 is a novel nuclear protein that interacts with Gadd45 and may play a role in the negative regulation of cell cycle progression and cell growth. PMID: 12716909
24. Data show that GADD45 gamma mRNA expression is down-regulated in hepatocellular carcinoma, and that GADD45 gamma causes cell cycle arrest at G2/M transition when transfected into Hep-G2 cells. PMID: 14672412
25. GADD45g induction by androgens requires new protein synthesis. Overexpression of GADD45g inhibited cell growth and caused morphological changes in prostate cell lines, indicating that GADD45g is involved in androgen-induced differentiation. PMID: 15062559
26. Inhibition of GADD45alpha and gamma in cancer cells by small interfering RNA abrogates apoptosis induction by the inhibitor of NF-κB. PMID: 15353598
27. Results indicate that GADD45G can function as a novel tumor suppressor, but it is frequently inactivated epigenetically in multiple tumors. PMID: 16166418
28. Studies establish MDA-7/IL-24 and GADD45alpha and GADD45gamma as critical mediators of apoptosis and growth arrest in response to NSAIDs in cancer cells. PMID: 17178890
29. Human Gadd45gamma and its selenomethionine derivative were expressed in an Escherichia coli expression system and purified. They were then crystallized using the hanging-drop vapor-diffusion method. PMID: 18997345
30. Urinary GADD45gamma expression is associated with the progression of renal disease. PMID: 19293565

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HGNC: 4097

OMIM: 604949

KEGG: hsa:10912

STRING: 9606.ENSP00000252506

UniGene: Hs.9701