LGALDH Antibody
Description
Potential Misidentification or Typographical Error
The term "LGALDH" does not correspond to any established:
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Gene symbol in the HUGO Gene Nomenclature Committee (HGNC) database
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Protein identifier in UniProt or Protein Data Bank (PDB)
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Antibody target in the Human Protein Atlas, Structural Antibody Database (SAbDab), or ClinicalTrials.gov
Analysis of Antibody Naming Conventions
Antibodies are typically named using standardized formats:
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Target-based: e.g., "anti-HER2 antibody"
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Clone-specific: e.g., "Rituximab (clone IDEC-C2B8)"
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Isotype/formatted: e.g., "IgG1κ"
"LGALDH" does not align with these conventions, suggesting a possible typographical error or misinterpretation of nomenclature.
Relevant Antibody Research Contexts
While "LGALDH Antibody" is unidentifiable, the provided sources highlight critical advancements in antibody science that may relate to broader research interests:
| Concept | Key Findings | Sources |
|---|---|---|
| Bispecific Antibodies | Engineered antibodies (e.g., hBS910) mimic coagulation factors for hemophilia therapy | 7,12 |
| Anti-Glycan mAbs | mAbs targeting sLeA/CA19-9 and LeY antigens show promise in pancreatic cancer diagnostics | 5 |
| Antibody Characterization | Initiatives like NeuroMab and YCharOS address reproducibility challenges in antibody validation | 4,6 |
| Tissue-Specific Clearance | Liver and skin degrade ~55% of IgG antibodies in mice, critical for pharmacokinetic modeling | 8 |
Recommendations for Further Inquiry
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Verify Terminology: Confirm if "LGALDH" refers to a novel target or a proprietary compound not yet published in open-access literature.
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Explore Analogous Targets: Investigate antibodies against lactate dehydrogenase (LDH) isoforms or galactose-related enzymes, which may align with the intended query.
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Consult Specialized Databases:
Product Specs
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
Target Background
- A single alanine to glycine substitution in l-galactono-gamma-lactone dehydrogenase (GALDH) converts the enzyme into a catalytically proficient oxidase. PMID: 19088070
- The E386D variant displays a loss of specificity for L-galactono-1,4-lactone and demonstrates the highest catalytic efficiency with L-gulono-1,4-lactone. PMID: 19737562
