GALS2 Antibody

Definition and Target Specificity

GALS2 antibody (e.g., catalog ABIN7431557) is a rabbit polyclonal antibody raised against recombinant Galectin-2 (GAL2), spanning amino acids 1–130 . Galectin-2 is a soluble lectin that binds galactosides and plays roles in immune cell activation, apoptosis, and inflammation .

Key Features of GALS2 Antibody (ABIN7431557)

Detection and Localization

The antibody is optimized for detecting Galectin-2 in:

• Western blotting: Identifies Galectin-2 in lysates (e.g., rat tissues) .

• Immunohistochemistry: Visualizes Galectin-2 expression in tissue sections (e.g., rat models) .

• Immunoprecipitation: Isolates Galectin-2 complexes for downstream analysis .

Functional Studies

Galectin-2’s role in immune regulation is critical. For example:

• Immune cell modulation: Galectin-2 interacts with pathogens and host cells to influence cytokine release and phagocytosis .

• Inflammation: Galectin-2 may bind to glycosphingolipids (GSLs) to modulate immune responses .

Comparative Analysis with Other Galectin Antibodies

While GALS2 antibody targets Galectin-2, other Galectin antibodies (e.g., anti-Galectin-1 or -3) have distinct specificities and applications.

Research Gaps and Future Directions

Current data on GALS2 antibody is limited to its technical specifications. Further studies are needed to:

• Expand cross-reactivity: Validate reactivity with human or other species.

• Explore therapeutic potential: Investigate Galectin-2’s role in diseases (e.g., cancer, autoimmunity) using this antibody.

• Optimize detection protocols: Standardize IHC/ICC conditions for consistent staining outcomes .