GASA11 Antibody
Description
GNA11 Antibody: Overview and Applications
GNA11 is a subunit of G-protein signaling complexes involved in phospholipase C (PLC) activation and downstream pathways. Antibodies targeting GNA11 are critical for studying its role in signaling, cancer, and developmental biology.
Research Findings
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Cancer Biology: GNA11 mutations are implicated in uveal melanoma and other cancers, where antibodies are used to study PLC-beta activation and tumorigenesis .
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Signaling Pathways: GNA11 mediates FFAR4 signaling in response to long-chain fatty acids and interacts with PLC-beta in lipid hydrolysis .
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Tissue Localization: Expressed in testicular cells (cytoplasmic) and membrane-bound in other tissues .
GAS1 Antibody: Functions and Research Applications
GAS1 is a growth-arrest-specific protein that modulates Hedgehog signaling, apoptosis, and cell proliferation. Antibodies targeting GAS1 are pivotal in oncology and developmental biology.
Research Findings
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Cancer Suppression: GAS1 overexpression inhibits glioblastoma cell proliferation and hepatocellular carcinoma progression .
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Neurodevelopment: Interacts with Hedgehog signaling to regulate neural tube closure and brain morphogenesis .
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Therapeutic Potential: GAS1 antibodies enable studies on tumor suppression and regenerative medicine .
Comparative Analysis of GNA11 and GAS1 Antibodies
Immunoglobulin Classes and Antibody Structure
Antibodies like those targeting GNA11 and GAS1 belong to the IgG class, which dominates serum immunoglobulins (75–80%) . Their structure includes:
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Fab Fragment: Antigen-binding regions (paratope).
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Fc Region: Mediates immune effector functions (complement activation, Fc receptor binding) .
IgG Properties
| Property | Detail |
|---|---|
| Molecular Weight | 150 kDa |
| Antigen-Binding Sites | 2 |
| Serum Concentration | 10–16 mg/mL |
| Glycosylation | 3% (N-glycosylation in Fc region) |
Future Directions and Challenges
Product Specs
Composition: 50% Glycerol, 0.01M PBS, pH 7.4
