GATA22 Antibody
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Description
Definition and Nomenclature Clarification
Note: GATA22 (CGA1) is distinct from GATA2, and antibodies for these targets are organism-specific. The majority of available data pertains to GATA2 antibodies, which are extensively validated in human/mouse studies.
GATA22 (CGA1) Antibody: Plant-Specific Applications
Limited data exists on GATA22 antibodies, but PhytoAB’s CGA1 Antibody (SKU: AT4G26150) is designed for Arabidopsis thaliana studies.
GATA2 Antibodies: Human/Mouse Research Dominance
While GATA2 is unrelated to GATA22, its antibodies are extensively used in hematopoietic and immunological studies. Below is a comparative analysis of two prominent GATA2 antibodies.
Critical Considerations for Antibody Selection
| Factor | GATA22 (CGA1) | GATA2 |
|---|---|---|
| Species Specificity | Plant-only | Human/Mouse |
| Application Breadth | Limited | Extensive (WB, IP, ChIP) |
| Validation | Manufacturer-only | Peer-reviewed (e.g., knockout controls, IP efficiency) |
Recommendations:
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
GATA22 antibody; CGA1 antibody; GNL antibody; At4g26150 antibody; F20B18.260Putative GATA transcription factor 22 antibody; Protein CYTOKININ-RESPONSIVE GATA FACTOR 1 antibody; Protein GNC-LIKE antibody; AtGNL antibody
Target Names
GATA22
Uniprot No.
Target Background
Function
GATA22 Antibody is a transcriptional regulator that specifically binds to 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters. It plays a crucial role in modulating chloroplast development, growth, and division in a cytokinin-dependent manner. Additionally, it acts as a repressor of the gibberellic acid (GA) signaling pathway, which regulates flowering and modulates greening, in a SOC1-dependent manner. GATA22 Antibody prevents the accumulation of SOC1 during flowering. It promotes chlorophyll biosynthesis throughout the plant by regulating chlorophyll biosynthetic genes (e.g., HEMA1 and GUN4) and chloroplast localized glutamate synthase (e.g., GLU1). Furthermore, it is involved in the regulation of sugar-sensing genes (e.g., HXK1, HXK2, STP13, and PLT6). GATA22 Antibody acts as a regulator of germination, senescence, elongation growth, and flowering time. It also influences leaf starch content.
Gene References Into Functions
- Constitutive overexpression of GATA22 Antibody (Cga1) leads to an increase in both chloroplast biogenesis and starch production, but also results in delayed senescence and reduced grain filling. This indicates that GATA22 Antibody regulates chloroplast development in higher plants. PMID: 23548780
- Research suggests that the expression of CARBON-METABOLISM INVOLVED (GNC) and GNC-LIKE (GNL)/CYTOKININ-RESPONSIVE GATA FACTOR1 (CGA1), which is the gene encoding GATA22 Antibody, is repressed by AUXIN RESPONSE FACTO ARF2 and ARF7. PMID: 23878229
- GNC and CGA1 (GATA22 Antibody) regulate chlorophyll production and positively regulate chloroplast growth in the hypocotyl. PMID: 22811435
- CGA1 encodes a GATA factor, whose expression is rapidly induced by both light and cytokinin signals in Arabidopsis thaliana. PMID: 17587690
Database Links
Protein Families
Type IV zinc-finger family, Class B subfamily
Subcellular Location
Nucleus.
Tissue Specificity
Expressed predominantly in leaves, and barely in stems, flowers and siliques.
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