GATA1 (Ab-310) Antibody

1. Reduced GATA-1 levels may be responsible for the upregulation of IRF-3 in lung adenocarcinoma cells through binding to a specific domain of the IRF-3 promoter. PMID: 28566697
2. A study described the functional interaction between GATA1 and SEC23B genes in two patients with suspected congenital dyserythropoietic anemia type II. PMID: 28550189
3. Research using zebrafish, murine, and human models demonstrates that erythropoietin (EPO) signaling, in conjunction with the GATA1 transcriptional target, AKAP10, regulates heme biosynthesis during erythropoiesis at the outer mitochondrial membrane. PMID: 28553927
4. Expression of GATA1 effectively rescued the maturation of primary myelofibrosis megakaryocytes. PMID: 28240607
5. GATA1 is a crucial downstream target of SENP1, and the differential expression and response of GATA1 and Bcl-xL represent a key mechanism underlying chronic mountain sickness pathology. PMID: 27821551
6. This study identified a long-distance regulatory region containing GATA1 binding sites as a potent enhancer for NBEAL2 expression. PMID: 28082341
7. A single-nucleotide polymorphism in the GATA1 gene has been associated with non-Down syndrome transient proliferative megakaryoblastic disease. PMID: 27667142
8. Findings suggest that erythroid-specific activator GATA-1 acts at CTCF sites surrounding the beta-globin locus to establish tissue-specific chromatin organization. PMID: 28161276
9. Results indicate that GATA1 recognizes a single GATA motif or a combination of adjacent GATA motifs, leading to diverse binding patterns. These binding configurations serve as a critical determinant of specific transcriptional regulation. PMID: 27215385
10. Both acquired and inherited GATA1 mutations contribute to Diamond-Blackfan anemia, acute megakaryoblastic leukemia, transient myeloproliferative disorder, and related congenital dyserythropoietic anemias with thrombocytopenia. PMID: 28179280
11. Findings suggest that GATAl and miR-363 are involved in the regulation of hematopoiesis via the HIF-1alpha pathway in K562 cells under hypoxic conditions. PMID: 27485543
12. Analysis of GATA1 mutations in a cohort of Malaysian children with Down syndrome-associated myeloid disorder reveals distinctive genomic events. PMID: 27353457
13. Trisomy 21 disrupts hematopoietic development through increased production of early hematopoietic progenitors and upregulation of mutated GATA1, resulting in accelerated production of aberrantly differentiated cells. PMID: 27134169
14. Data demonstrate that pyruvate kinase (PK) activity is decreased in the GATA1 hemizygous state and PKLR c.1284delA variant. PMID: 27342114
15. GATA1 mutations have been identified in consecutive Down syndrome patients with transient myeloproliferative disorder or acute leukemia. PMID: 26234152
16. Expression of GATA1 and SET7 is upregulated and positively correlated with VEGF expression and microvessel number in 80 breast cancer patients. GATA1 and SET7 are independent poor prognostic factors in breast cancer. PMID: 26848522
17. Molecular cytogenetic analysis of leukemic blast cells indicated that increased blast cell status was caused by transient abnormal myelopoiesis with trisomy 21 and GATA1 mutation. PMID: 25711269
18. Deletion of P-selectin disrupted megakaryocyte/neutrophil interactions in the spleen, reduced TGF-beta content, and corrected the hematopoietic stem cells distribution, which is abnormally expanded in the spleen of Gata1(low) mice, similar to primary myelofibrosis patients. PMID: 26439305
19. This study provides insight into GATA1 transcriptional activity and may prove a valuable resource for investigating the pathogenicity of noncoding variants in human erythroid disorders. PMID: 27044088
20. The GATA-1-mediated inhibition of PU.1 gene transcription in human AML-erythroleukemias through the URE represents a significant mechanism contributing to PU.1 downregulation and leukemogenesis that is sensitive to DNA demethylation therapy. PMID: 27010793
21. These findings provide insights into the clinically relevant in vivo function of the N-terminal domain of GATA1 in human hematopoiesis. PMID: 26713410
22. Acute megakaryoblastic leukemia is associated with GATA-1 mutation, mimicking myeloproliferative disorders. PMID: 26205501
23. A GATA2-to-GATA1 switch is prevalent at dynamic enhancers and drives erythroid enhancer commissioning. PMID: 26766440
24. GATA1 and GATA2 are implicated in clear cell renal cell carcinoma biology, potentially impacting tumor development and aggressiveness. PMID: 25230694
25. Congenital erythropoietic porphyria has been linked to a GATA1-R216W mutation. PMID: 25251786
26. Research has uncovered a novel role for GATA1 in regulating epithelial-mesenchymal transition. PMID: 25726523
27. Global transcriptome and chromatin occupancy analysis reveals that the short isoform of GATA1 is deficient in erythroid specification and gene expression. PMID: 25682601
28. EDAG forms a complex with GATA1 and p300, enhancing GATA1 acetylation and transcriptional activity by facilitating the interaction between GATA1 and p300. PMID: 24740910
29. These results suggest that KLF1 plays a role in facilitating and/or stabilizing GATA-1 and TAL1 occupancy in erythroid genes, contributing to the formation of active chromatin structure, such as histone acetylation and chromatin looping. PMID: 25528728
30. Our case of transient leukemia without Down syndrome highlights the significant role of trisomy 21 and GATA1 mutation in the development of transient neonatal leukemia. PMID: 24253371
31. In erythroid cells, pull-down experiments identified a novel complex formed by HDAC5, GATA1, EKLF, and pERK, which was not detected in cells of the megakaryocytic lineage. PMID: 24594363
32. Results demonstrate that expression of the hGATA1 gene is regulated through the chromatin architecture organized by 5'CTCF site-mediated intrachromosomal interactions in the hGATA1 locus. PMID: 25755285
33. The results demonstrate that hGATA-1 and hGATA-2 expression in the hippocampus is sufficient to cause depressive-like behaviors. PMID: 25340772
34. Lineage-specific GATA1 cofactor associations are essential for normal chromatin occupancy. PMID: 25621499
35. Nkx2-5 binds to the Gata1 gene enhancer and represses the transcriptional activity of the Gata1 gene. PMID: 21464046
36. A hypothesis is presented to explain that, in Down syndrome, the initial mutational events, GATA1 somatic mutations, do not occur randomly, but as a result of perturbed cell functions and specific overexpression of the GATA1 gene. PMID: 24880866
37. Data indicate that GATA1 transcription factor is downregulated in ribosomal protein S19 (RPS19)-deficient cells through upregulation of TNF-alpha and p38 MAPK. PMID: 25270909
38. A functional link exists among the erythroid transcription factors GATA-1/NF-E2, and miR-199b-5p in erythropoiesis. PMID: 24608802
39. Somatic GATA1 mutations appear to be pivotal in the development of transient abnormal myelopoiesis and are proving to be markers of clonal identity in its evolution to acute megakaryoblastic leukemia in subjects with Down syndrome. [CASE STUDY; REVIEW] PMID: 25268193
40. The high rate of GATA-1 gene mutations was confirmed in newborn infants with Down's Syndrome and transient abnormal myelopoiesis or acute megakaryoblastic leukemia. PMID: 24196768
41. Results report a fourth family with clinical findings consistent with an association between GATA1 gene mutation and Diamond-Blackfan anemia. PMID: 24766296
42. The amplitude of a transcriptional signature of GATA1 target genes was globally and specifically reduced, indicating that the activity, but not the mRNA level, of GATA1 is decreased in patients with DBA. PMID: 24952648
43. PSTPIP2 dysregulation contributes to aberrant terminal differentiation in GATA-1-deficient megakaryocytes by activating LYN. PMID: 24407241
44. High GATA1 expression is associated with hyperproliferation of eosinophil precursors in Down syndrome transient leukemia. PMID: 24336126
45. Mutations in the GATA1 gene are associated with leukemogenesis in newborns with Down syndrome. PMID: 24222239
46. Loss of GATA-1 full length is a cause of the Diamond-Blackfan anemia phenotype. PMID: 24453067
47. Mitochondrial translation is dramatically affected after mGatA depletion, revealing an essential role for the GatCAB enzyme in the process of protein biosynthesis in mammalian mitochondria. PMID: 24579914
48. Our results suggest that GATA1 exon 2 mutations occur late in trisomy 21 fetal hematopoiesis. PMID: 24746204
49. A role for GATA1 in chemotherapy resistance in non-Down syndrome acute megakaryocytic leukemia cells. PMID: 23874683
50. Multiple modes of the GATA1-MED1 axis may help to fine-tune GATA1 function during GATA1-mediated homeostasis events. PMID: 24245781

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HGNC: 4170

OMIM: 300367

KEGG: hsa:2623

STRING: 9606.ENSP00000365858

UniGene: Hs.765