GBF4 Antibody

Related Antibodies and Their Targets

While "GBF4 Antibody" is not documented, the following antibodies are notable for their specificity to similar or analogous targets:

Gb4Cer Antibodies

• Immunogenicity: Gb4Cer-VLCFAs (globotetraosylceramide with very-long-chain fatty acids) induce robust antibody responses in mice, including IgG3 and IgM subclasses. These antibodies recognize epitopes shared with Gb3Cer (a precursor glycosphingolipid) .

• Pathological Roles: Gb4Cer promotes EGFR-mediated ERK signaling in cancer cells, enhancing proliferation. Depletion of Gb4Cer reduces ERK activation and cell growth .

BG4 Antibody

• Specificity: Targets DNA G-quadruplex structures, which are stable, guanine-rich DNA motifs implicated in genomic stability and cancer .

• Applications:

  • ChIP-seq: Maps G-quadruplex formation in genomic regions.

  • Immunocytochemistry: Visualizes G-quadruplex localization in cells.

Potential Overlaps or Misinterpretations

The term "GBF4" might refer to:

1. Glypican 4 (GPC4): A heparan sulfate proteoglycan involved in developmental signaling. Antibodies against GPC4 are used in cancer research (e.g., neuroblastoma, breast cancer) .

2. G-quadruplex-binding fragments: BG4 antibody or SG4 nanobodies target these structures, which are implicated in DNA replication and transcription .

3. Globosides: Gb4Cer antibodies study lipid signaling in autoimmune and cancer contexts .

Recommendations for Further Research

1. Clarify Nomenclature: Verify whether "GBF4" refers to a novel target or a misidentified antibody.

2. Explore Structural Analogs: Investigate antibodies targeting G-quadruplexes (BG4), glycosphingolipids (Gb4Cer), or heparan sulfate proteoglycans (GPC4).

3. IgG4 Biology: Study IgG4 antibodies’ roles in immune tolerance or cancer immunity, leveraging their unique properties .