GAMMACA1 Antibody

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Cat. No.
BT1237417
Synonyms
GAMMACA1 antibody; At1g19580 antibody; F14P1.8 antibody; F18O14.34 antibody; Gamma carbonic anhydrase 1 antibody; mitochondrial antibody; AtCA1 antibody; GAMMA CA1 antibody; EC 4.2.1.- antibody
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Description

Key Features:

  • Heavy chain composition: IgG1 antibodies contain two heavy chains with constant (Cγ1), hinge, and variable regions .

  • Effector functions: IgG1 engages activating Fcγ receptors (FcγRIIA, FcγRI) and complements (C1q), enabling antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis (ADCP) .

  • Glycosylation: Critical for FcγR binding; mutations like N297A abolish effector functions .

AMPK Gamma 1 Antibody (67182-1-Ig)

  • Target: AMP-activated protein kinase (AMPK) γ1 subunit, a metabolic regulator .

  • Applications:

    ParameterDetails
    Tested ReactivityHuman, mouse, rat
    Host/IsotypeMouse IgG1
    Molecular Weight36–38 kDa
    Recommended Dilution (WB)1:5,000–1:20,000
    Therapeutic RelevanceInvestigated in cancer and metabolic disorders due to AMPK's role in energy homeostasis .

GABA A Receptor Gamma 1 Antibody (ab74327)

  • Target: Gamma-aminobutyric acid receptor γ1 subunit, critical for inhibitory neurotransmission .

  • Applications:

    ParameterDetails
    Host/IsotypeRabbit polyclonal IgG
    ImmunogenSynthetic peptide within human GABRG1
    Functional InsightsModulates chloride channel activity; linked to epilepsy and anxiety disorders .

Phospholipase C Gamma 1 Antibody (ab302941)

  • Target: PLCγ1, a signaling enzyme in growth factor pathways .

  • Applications:

    ParameterDetails
    Host/IsotypeMouse IgG1
    Validated SpeciesHuman, mouse, rat
    Role in CancerOverexpressed in malignancies; targeted to inhibit oncogenic signaling .

Research Findings and Therapeutic Implications

  • FcγR Engagement: Antibodies like anti-GITR (DTA-1) require activating FcγRs (e.g., FcγRIII) for antitumor efficacy, as shown in murine models .

  • Effector-Attentuation: Mutations (e.g., LALA-PG) in IgG1 Fc regions reduce complement binding (C1q) by >50% while maintaining stability .

  • Genetic Diversity: Polymorphisms in IgG1 constant domains (e.g., G1m allotypes) influence effector functions and therapeutic efficacy .

Data Tables: Comparative Analysis of γ1-Targeting Antibodies

AntibodyTarget PathwayHost/IsotypeKey ApplicationTherapeutic Area
AMPK Gamma 1 (67182-1-Ig)Metabolic regulationMouse IgG1Western blot, ELISACancer, Diabetes
GABA A γ1 (ab74327)NeurotransmissionRabbit IgGImmunofluorescenceNeurological disorders
PLCγ1 (ab302941)Cell signalingMouse IgG1WB, ICC/IFOncology

Product Specs

Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
GAMMACA1 antibody; At1g19580 antibody; F14P1.8 antibody; F18O14.34 antibody; Gamma carbonic anhydrase 1 antibody; mitochondrial antibody; AtCA1 antibody; GAMMA CA1 antibody; EC 4.2.1.- antibody
Target Names
GAMMACA1
Uniprot No.
Q9FWR5

Target Background

Function
This enzyme participates in the catabolism of H(2)CO(3) but does not mediate the reversible hydration of carbon dioxide. It plays a crucial role in complex I assembly within mitochondria, which is essential for respiration.
Gene References Into Functions
  1. AT1G19580 is essential for complex I assembly, and reproductive development is dependent on the presence of complex I. PMID: 26889912
  2. AT1G19580 contributes to maintaining efficient photosynthesis under ambient (photorespiratory) conditions. PMID: 26148112
Database Links

KEGG: ath:AT1G19580

STRING: 3702.AT1G19580.1

UniGene: At.28167

Protein Families
Gamma-class carbonic anhydrase family
Subcellular Location
Mitochondrion membrane; Peripheral membrane protein; Matrix side.

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