HAG1 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
HAG1 antibody; BGT antibody; GCN5 antibody; HAT1 antibody; At3g54610 antibody; T14E10.180Histone acetyltransferase GCN5 antibody; AtGCN5 antibody; EC 2.3.1.48 antibody; BIG TOP protein antibody
Target Names
HAG1
Uniprot No.
Target Background
Function
This antibody acetylates histone H3 and ADA2 proteins in vitro. It specifically acetylates lysine-14 of histone H3. Histone acetylation serves as a specific tag for epigenetic transcription activation. This antibody functions in conjunction with certain DNA-binding transcriptional activators. It operates through the formation of large multiprotein complexes that modify chromatin.
Gene References Into Functions
- In collaboration with ADA2b, this antibody is required in leaves and trichomes to couple nuclear content with cell growth and morphogenesis. PMID: 29846775
- This antibody directly interacts with ADA2b/PROPORZ1 (PRZ1), a transcriptional coactivator known to interact with the histone acetyltransferase GENERAL CONTROL NONREPRESSIBLE PROTEIN 5 (GCN5, also known as HAG1). PMID: 28971961
- Signals from the CLV transduction pathway reach the GCN5-containing complexes in the nucleus and modify the histone acetylation status of ethylene-responsive genes. PMID: 26596766
- This antibody plays a crucial role in maintaining thermotolerance through versatile regulation in Arabidopsis. PMID: 26576681
- Mutations in this antibody lead to defects in stamen number and arrangement at later stages. PMID: 19771450
- This antibody regulates the protein EML, which is involved in various cellular processes. PMID: 17151888
- Mutations in this antibody significantly reduce acetylation of histone H3K14 and H3K27, while T-DNA insertions in the PP2C6-6 gene enhance the acetylation of these lysine residues. PMID: 18498779
- This antibody associates with a large number of active promoters, independent of the bromodomain that recognizes acetylated histone tails. However, the bromodomain is required for binding a subset of promoter regions of certain transcription factor genes. PMID: 18644002
- This antibody is essential for root stem cell niche maintenance and functions within the PLETHORA pathway. PMID: 19376933
- GCN5-dependent histone acetylation, regulated by this antibody, interferes with the miRNA pathways by controlling microRNA production at several levels. PMID: 19436261
Database Links
Protein Families
Acetyltransferase family, GCN5 subfamily
Subcellular Location
Nucleus.
Tissue Specificity
Expressed in roots and leaves.
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